Human Gene FKBP1A (uc002wey.3)
  Description: Homo sapiens FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 1, mRNA.
RefSeq Summary (NM_000801): The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008].
Transcript (Including UTRs)
   Position: hg19 chr20:1,349,621-1,373,816 Size: 24,196 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr20:1,352,756-1,373,642 Size: 20,887 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:1,349,621-1,373,816)mRNA (may differ from genome)Protein (108 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FKB1A_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP1A; Short=PPIase FKBP1A; EC=5.2.1.8; AltName: Full=12 kDa FK506-binding protein; Short=12 kDa FKBP; Short=FKBP-12; AltName: Full=Calstabin-1; AltName: Full=FK506-binding protein 1A; Short=FKBP-1A; AltName: Full=Immunophilin FKBP12; AltName: Full=Rotamase;
FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
ENZYME REGULATION: Inhibited by both FK506 and rapamycin.
SUBUNIT: Interacts directly with RYR1, RYR2 and RYR3. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with ACVR1B and SMAD7.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
SIMILARITY: Contains 1 PPIase FKBP-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FKBP1A
CDC HuGE Published Literature: FKBP1A
Positive Disease Associations: Apolipoproteins C , Arteries
Related Studies:
  1. Apolipoproteins C
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  2. Arteries
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: FKBP1A
Diseases sorted by gene-association score: left ventricular noncompaction (3), reticulate acropigmentation of kitamura (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 177.84 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 3702.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -95.10174-0.547 Picture PostScript Text
3' UTR -334.201132-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase

SCOP Domains:
54534 - FKBP-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A7X - X-ray MuPIT 1B6C - X-ray MuPIT 1BKF - X-ray MuPIT 1BL4 - X-ray MuPIT 1D6O - X-ray MuPIT 1D7H - X-ray MuPIT 1D7I - X-ray MuPIT 1D7J - X-ray MuPIT 1EYM - X-ray MuPIT 1F40 - NMR MuPIT 1FAP - X-ray 1FKB - X-ray MuPIT 1FKD - X-ray MuPIT 1FKF - X-ray MuPIT 1FKG - X-ray MuPIT 1FKH - X-ray MuPIT 1FKI - X-ray MuPIT 1FKJ - X-ray MuPIT 1FKR - NMR MuPIT 1FKS - NMR MuPIT 1FKT - NMR MuPIT 1J4H - X-ray MuPIT 1J4I - X-ray MuPIT 1J4R - X-ray MuPIT 1NSG - X-ray 1QPF - X-ray MuPIT 1QPL - X-ray MuPIT 2DG3 - X-ray MuPIT 2DG4 - X-ray MuPIT 2DG9 - X-ray MuPIT 2FAP - X-ray 2FKE - X-ray MuPIT 2PPN - X-ray MuPIT 2PPO - X-ray MuPIT 2PPP - X-ray MuPIT 2RSE - NMR MuPIT 3FAP - X-ray MuPIT 3H9R - X-ray MuPIT 3MDY - X-ray MuPIT 4DH0 - X-ray MuPIT 4FAP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P62942
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0005527 macrolide binding
GO:0005528 FK506 binding
GO:0016853 isomerase activity
GO:0034713 type I transforming growth factor beta receptor binding
GO:0044325 ion channel binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0019855 calcium channel inhibitor activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0003007 heart morphogenesis
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0007183 SMAD protein complex assembly
GO:0022417 protein maturation by protein folding
GO:0031398 positive regulation of protein ubiquitination
GO:0032092 positive regulation of protein binding
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032880 regulation of protein localization
GO:0032925 regulation of activin receptor signaling pathway
GO:0042026 protein refolding
GO:0042110 T cell activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050776 regulation of immune response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060347 heart trabecula formation
GO:0061077 chaperone-mediated protein folding
GO:0070588 calcium ion transmembrane transport
GO:0097435 supramolecular fiber organization
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1990000 amyloid fibril formation
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0014802 terminal cisterna
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0031312 extrinsic component of organelle membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0098562 cytoplasmic side of membrane
GO:1990425 ryanodine receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK309026 - Homo sapiens cDNA, FLJ99067.
BC001925 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone MGC:3950 IMAGE:2823635), complete cds.
JA482230 - Sequence 213 from Patent WO2011072091.
JE980522 - Sequence 213 from Patent EP2862929.
M34539 - Human FK506-binding protein (FKBP) mRNA, complete cds.
JD163620 - Sequence 144644 from Patent EP1572962.
JD201732 - Sequence 182756 from Patent EP1572962.
JD449584 - Sequence 430608 from Patent EP1572962.
JD449583 - Sequence 430607 from Patent EP1572962.
JD302923 - Sequence 283947 from Patent EP1572962.
JD288785 - Sequence 269809 from Patent EP1572962.
JD247547 - Sequence 228571 from Patent EP1572962.
JD123316 - Sequence 104340 from Patent EP1572962.
JD320698 - Sequence 301722 from Patent EP1572962.
JD403984 - Sequence 385008 from Patent EP1572962.
JD129971 - Sequence 110995 from Patent EP1572962.
JD314663 - Sequence 295687 from Patent EP1572962.
JD284797 - Sequence 265821 from Patent EP1572962.
JD391466 - Sequence 372490 from Patent EP1572962.
JD528231 - Sequence 509255 from Patent EP1572962.
BC119732 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone MGC:149764 IMAGE:40118164), complete cds.
BC119733 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone IMAGE:40118165), complete cds.
JD392476 - Sequence 373500 from Patent EP1572962.
JD376964 - Sequence 357988 from Patent EP1572962.
JD546407 - Sequence 527431 from Patent EP1572962.
JD270098 - Sequence 251122 from Patent EP1572962.
JD270099 - Sequence 251123 from Patent EP1572962.
JD338063 - Sequence 319087 from Patent EP1572962.
JA482229 - Sequence 212 from Patent WO2011072091.
JE980521 - Sequence 212 from Patent EP2862929.
X52220 - Human FKBP mRNA for FK-506 binding protein.
BC005147 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone MGC:2167 IMAGE:3504715), complete cds.
AB241124 - Homo sapiens FKBP12-Exip3 mRNA for FK506 binding protein12, complete cds.
AB241123 - Homo sapiens FKBP12-Exip2 mRNA for FK506 binding protein12, complete cds.
AB241125 - Homo sapiens FKBP12-Exin mRNA for FK506 binding protein12, complete cds.
CR542168 - Homo sapiens full open reading frame cDNA clone RZPDo834C0724D for gene FKBP1A, FK506 binding protein 1A, 12kDa; complete cds, incl. stopcodon.
KJ896819 - Synthetic construct Homo sapiens clone ccsbBroadEn_06213 FKBP1A gene, encodes complete protein.
BT007066 - Homo sapiens FK506 binding protein 1A, 12kDa mRNA, complete cds.
DQ891819 - Synthetic construct clone IMAGE:100004449; FLH180261.01X; RZPDo839A04134D FK506 binding protein 1A, 12kDa (FKBP1A) gene, encodes complete protein.
KJ904464 - Synthetic construct Homo sapiens clone ccsbBroadEn_13858 FKBP1A gene, encodes complete protein.
CR407613 - Homo sapiens full open reading frame cDNA clone RZPDo834F016D for gene FKBP1A, FK506 binding protein 1A, 12kDa complete cds, without stopcodon.
E03395 - DNA encoding FK506 binding protein.
AB463639 - Synthetic construct DNA, clone: pF1KB3544, Homo sapiens FKBP1A gene for FK506 binding protein 1A, without stop codon, in Flexi system.
AF205192 - Homo sapiens FKBP-12 mRNA, partial cds.
D28444 - Homo sapiens mRNA for FK506-binding protein, 5'UTR region.
JD173888 - Sequence 154912 from Patent EP1572962.
JD240635 - Sequence 221659 from Patent EP1572962.
MP015226 - Sequence 429 from Patent WO2019016252.
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MA874501 - JP 2018536436-A/6337: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874797 - JP 2018536436-A/6633: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874500 - JP 2018536436-A/6336: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874795 - JP 2018536436-A/6631: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874499 - JP 2018536436-A/6335: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874794 - JP 2018536436-A/6630: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874498 - JP 2018536436-A/6334: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874793 - JP 2018536436-A/6629: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874497 - JP 2018536436-A/6333: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874792 - JP 2018536436-A/6628: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874496 - JP 2018536436-A/6332: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874791 - JP 2018536436-A/6627: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874495 - JP 2018536436-A/6331: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874790 - JP 2018536436-A/6626: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874494 - JP 2018536436-A/6330: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874789 - JP 2018536436-A/6625: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874493 - JP 2018536436-A/6329: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874492 - JP 2018536436-A/6328: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874491 - JP 2018536436-A/6327: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874490 - JP 2018536436-A/6326: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
MA874489 - JP 2018536436-A/6325: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597073 - KR 1020180133840-A/6497: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY597070 - KR 1020180133840-A/6494: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597069 - KR 1020180133840-A/6493: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY597067 - KR 1020180133840-A/6491: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY597063 - KR 1020180133840-A/6487: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY597032 - KR 1020180133840-A/6456: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597031 - KR 1020180133840-A/6455: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597030 - KR 1020180133840-A/6454: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597029 - KR 1020180133840-A/6453: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597025 - KR 1020180133840-A/6449: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597024 - KR 1020180133840-A/6448: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597001 - KR 1020180133840-A/6425: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597000 - KR 1020180133840-A/6424: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596999 - KR 1020180133840-A/6423: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596998 - KR 1020180133840-A/6422: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597288 - KR 1020180133840-A/6749: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596997 - KR 1020180133840-A/6421: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597287 - KR 1020180133840-A/6748: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596996 - KR 1020180133840-A/6420: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597286 - KR 1020180133840-A/6747: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596995 - KR 1020180133840-A/6419: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597284 - KR 1020180133840-A/6745: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596994 - KR 1020180133840-A/6418: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597277 - KR 1020180133840-A/6738: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596993 - KR 1020180133840-A/6417: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597275 - KR 1020180133840-A/6736: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596992 - KR 1020180133840-A/6416: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597274 - KR 1020180133840-A/6735: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596991 - KR 1020180133840-A/6415: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597272 - KR 1020180133840-A/6733: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596990 - KR 1020180133840-A/6414: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596979 - KR 1020180133840-A/6403: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597265 - KR 1020180133840-A/6726: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596978 - KR 1020180133840-A/6402: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597264 - KR 1020180133840-A/6725: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596977 - KR 1020180133840-A/6401: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597263 - KR 1020180133840-A/6724: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596976 - KR 1020180133840-A/6400: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597262 - KR 1020180133840-A/6723: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596975 - KR 1020180133840-A/6399: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597261 - KR 1020180133840-A/6722: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596974 - KR 1020180133840-A/6398: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597260 - KR 1020180133840-A/6721: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596973 - KR 1020180133840-A/6397: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597259 - KR 1020180133840-A/6720: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596972 - KR 1020180133840-A/6396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597258 - KR 1020180133840-A/6719: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596971 - KR 1020180133840-A/6395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597255 - KR 1020180133840-A/6716: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596970 - KR 1020180133840-A/6394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597251 - KR 1020180133840-A/6712: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596969 - KR 1020180133840-A/6393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597250 - KR 1020180133840-A/6711: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596968 - KR 1020180133840-A/6392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597249 - KR 1020180133840-A/6710: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY596953 - KR 1020180133840-A/6377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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LY596951 - KR 1020180133840-A/6375: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596950 - KR 1020180133840-A/6374: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596949 - KR 1020180133840-A/6373: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597244 - KR 1020180133840-A/6705: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596948 - KR 1020180133840-A/6372: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597239 - KR 1020180133840-A/6700: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596947 - KR 1020180133840-A/6371: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596921 - KR 1020180133840-A/6345: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596920 - KR 1020180133840-A/6344: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597233 - KR 1020180133840-A/6694: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596919 - KR 1020180133840-A/6343: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597230 - KR 1020180133840-A/6691: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596918 - KR 1020180133840-A/6342: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597228 - KR 1020180133840-A/6689: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596917 - KR 1020180133840-A/6341: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597226 - KR 1020180133840-A/6687: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596916 - KR 1020180133840-A/6340: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597225 - KR 1020180133840-A/6686: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596915 - KR 1020180133840-A/6339: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597212 - KR 1020180133840-A/6673: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596914 - KR 1020180133840-A/6338: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597210 - KR 1020180133840-A/6671: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596913 - KR 1020180133840-A/6337: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597209 - KR 1020180133840-A/6670: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596912 - KR 1020180133840-A/6336: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597207 - KR 1020180133840-A/6668: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596911 - KR 1020180133840-A/6335: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597206 - KR 1020180133840-A/6667: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596910 - KR 1020180133840-A/6334: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597205 - KR 1020180133840-A/6666: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596909 - KR 1020180133840-A/6333: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597204 - KR 1020180133840-A/6665: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596908 - KR 1020180133840-A/6332: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597203 - KR 1020180133840-A/6664: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596907 - KR 1020180133840-A/6331: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597202 - KR 1020180133840-A/6663: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596906 - KR 1020180133840-A/6330: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY597201 - KR 1020180133840-A/6662: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596905 - KR 1020180133840-A/6329: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596904 - KR 1020180133840-A/6328: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596903 - KR 1020180133840-A/6327: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596902 - KR 1020180133840-A/6326: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
LY596901 - KR 1020180133840-A/6325: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P62942 (Reactome details) participates in the following event(s):

R-HSA-170846 TGFBR2 recruits TGFBR1
R-HSA-2134519 TGFBR2 is recruited to tight junctions after TGF-beta stimulation
R-HSA-3645786 TGFBR2 mutant dimers recruit TGFBR1
R-HSA-3656484 TGFBR2 recruits TGFBR1 KD Mutants
R-HSA-2134506 TGFBR1 is recruited to tight junctions by PARD6A
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3656532 TGFBR1 KD Mutants in Cancer
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-3642278 Loss of Function of TGFBR2 in Cancer
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer
R-HSA-162582 Signal Transduction
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: D3DVW6, FKB1A_HUMAN, FKBP1, FKBP12, NM_000801, NP_463460, P20071, P62942, Q4VC47, Q6FGD9, Q6LEU3, Q9H103, Q9H566
UCSC ID: uc002wey.3
RefSeq Accession: NM_000801
Protein: P62942 (aka FKB1A_HUMAN or FKB1_HUMAN)
CCDS: CCDS13014.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_000801.4
exon count: 5CDS single in 3' UTR: no RNA size: 1643
ORF size: 327CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 854.00frame shift in genome: no % Coverage: 99.39
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.