Description: Homo sapiens interleukin 3 (colony-stimulating factor, multiple) (IL3), mRNA. RefSeq Summary (NM_000588): The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr5:131,396,347-131,398,896 Size: 2,550 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr5:131,396,400-131,398,484 Size: 2,085 Coding Exon Count: 5
ID:IL3_HUMAN DESCRIPTION: RecName: Full=Interleukin-3; Short=IL-3; AltName: Full=Hematopoietic growth factor; AltName: Full=Mast cell growth factor; Short=MCGF; AltName: Full=Multipotential colony-stimulating factor; AltName: Full=P-cell-stimulating factor; Flags: Precursor; FUNCTION: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. SUBUNIT: Monomer. INTERACTION: P32927:CSF2RB; NbExp=1; IntAct=EBI-1811718, EBI-1809771; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer cells. SIMILARITY: Belongs to the IL-3 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IL3ID60.html"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il3/";
asthma; atopy Park, B. L. et al. 2004, Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy., Journal of human genetics. 2004 ;49(10):517-27.
[PubMed 15372320]
This information about the genetic association of important genes with asthma might provide valuable insights into strategies for the pathogenesis of asthma and atopy.
Crohn Disease Eimear E Kenny et al. PLoS genetics 2012, A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci., PLoS genetics.
[PubMed 22412388]
rheumatoid arthritis Yamada R et al. 2001, Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to t, American journal of human genetics. 2001 Mar;68(3):674-85.
[PubMed 11179015]
Comparison of cases of RA versus control individuals yielded a chi(2) value of 14.28 (P=.0002), with a genotype odds ratio of 2.24 (95% confidence interval [95%CI] 1.44-3.49). Combined genotype data on SNPs on eight other candidate genes were combined with our IL-3 results, to estimate relationships between pairs of loci and RA, by maximum-likelihood analysis. The utility of combining the genotype data in this way to identify possible contributions of various genes to this disease is discussed.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08700
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04210 - Apoptosis hsa04630 - Jak-STAT signaling pathway hsa04640 - Hematopoietic cell lineage hsa04664 - Fc epsilon RI signaling pathway hsa05310 - Asthma
BioCarta from NCI Cancer Genome Anatomy Project h_erythPathway - Erythrocyte Differentiation Pathway h_badPathway - Regulation of BAD phosphorylation h_cytokinePathway - Cytokine Network h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy h_inflamPathway - Cytokines and Inflammatory Response h_stemPathway - Regulation of hematopoiesis by cytokines h_il17Pathway - IL 17 Signaling Pathway h_il3Pathway - IL 3 signaling pathway h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development
Reactome (by CSHL, EBI, and GO)
Protein P08700 (Reactome details) participates in the following event(s):
R-HSA-450074 Interleukin-3 receptor alpha subunit binds Interleukin-3 R-HSA-450031 Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 R-HSA-879907 Tyrosine kinases phosphorylate the receptor R-HSA-879910 JAK2 is phosphorylated, activated R-HSA-913451 IL3RB is phosphorylated on Ser-585 R-HSA-879930 STAT5 is recruited by JAK2 R-HSA-921155 p-STAT5 dissociates from the receptor complex R-HSA-879934 Recruitment of SHC1 is mediated by Y593 of the common beta chain R-HSA-909738 SHP1 and SHP2 bind the common beta chain R-HSA-912757 p-S585-IL3RB binds 14-3-3 proteins R-HSA-879909 Activation of STAT5a/b by JAK2 R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylated R-HSA-914036 SHP1 and SHP2 dephosphorylate Y628 of IL3RB R-HSA-914182 14-3-3 zeta binding allows recruitment of PI3K R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1 R-HSA-913374 Phosphorylated SHC1 recruits SHIP R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2 R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-449147 Signaling by Interleukins R-HSA-8878171 Transcriptional regulation by RUNX1 R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-212436 Generic Transcription Pathway R-HSA-168256 Immune System R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-912526 Interleukin receptor SHC signaling R-HSA-451927 Interleukin-2 family signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5683057 MAPK family signaling cascades R-HSA-162582 Signal Transduction
US Server
