Human Gene AVIL (ENST00000257861.7) Description and Page Index
Description: Homo sapiens advillin (AVIL), mRNA. (from RefSeq NM_006576) RefSeq Summary (NM_006576): The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF041449.1, SRR1803612.152633.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000257861.7 Gencode Gene: ENSG00000135407.10 Transcript (Including UTRs) Position: hg38 chr12:57,797,882-57,816,471 Size: 18,590 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chr12:57,797,882-57,816,040 Size: 18,159 Coding Exon Count: 19
ID:AVIL_HUMAN DESCRIPTION: RecName: Full=Advillin; AltName: Full=p92; FUNCTION: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. SUBUNIT: Associates (via C-terminus) with actin. Interacts with SCARF1 (By similarity). Interacts with F-actin. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection (By similarity). Cell projection, axon (By similarity). TISSUE SPECIFICITY: Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. SIMILARITY: Belongs to the villin/gelsolin family. SIMILARITY: Contains 6 gelsolin-like repeats. SIMILARITY: Contains 1 HP (headpiece) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75366
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.