Human Gene SELENOF (ENST00000331835.10) Description and Page Index
  Description: Homo sapiens selenoprotein F (SELENOF), transcript variant 1, mRNA. (from RefSeq NM_004261)
RefSeq Summary (NM_004261): The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016].
Gencode Transcript: ENST00000331835.10
Gencode Gene: ENSG00000183291.17
Transcript (Including UTRs)
   Position: hg38 chr1:86,862,445-86,914,126 Size: 51,682 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr1:86,863,474-86,914,111 Size: 50,638 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:86,862,445-86,914,126)mRNA (may differ from genome)Protein (165 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=15 kDa selenoprotein; Flags: Precursor;
FUNCTION: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).
SUBUNIT: Forms a tight complex with UGGT1/UGCGL1 (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
TISSUE SPECIFICITY: Higher levels in prostate and thyroid gland.
PTM: The N-terminus is blocked.
MASS SPECTROMETRY: Mass=14870; Method=Electrospray; Range=26-162; Source=PubMed:9535873;
MASS SPECTROMETRY: Mass=14830; Method=MALDI; Range=26-162; Source=PubMed:9535873;
SIMILARITY: Belongs to the selenoprotein M/SEP15 family.
SEQUENCE CAUTION: Sequence=AAH05294.3; Type=Erroneous initiation; Sequence=AAH16359.3; Type=Erroneous initiation; Sequence=AAH21697.3; Type=Erroneous initiation;

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.19 RPKM in Cells - Cultured fibroblasts
Total median expression: 2253.18 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -201.901029-0.196 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014912 - Sep15_SelM
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF08806 - Sep15/SelM redox domain

ModBase Predicted Comparative 3D Structure on O60613
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051084 'de novo' posttranslational protein folding

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen

-  Descriptions from all associated GenBank mRNAs
  AK225640 - Homo sapiens mRNA for 15 kDa selenoprotein precursor variant, clone: SPL08543.
BC016359 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:24512 IMAGE:4096759), complete cds.
AF288991 - Homo sapiens 15 kDa selenoprotein (SEP15) mRNA, complete cds; alternatively spliced.
AK225252 - Homo sapiens mRNA for 15 kDa selenoprotein precursor variant, clone: DMC03465.
AL833575 - Homo sapiens mRNA; cDNA DKFZp686D2056 (from clone DKFZp686D2056).
AF051894 - Homo sapiens 15 kDa selenoprotein mRNA, complete cds.
BC005294 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:12358 IMAGE:4041321), complete cds.
BC021697 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:24367 IMAGE:4051151), complete cds.
KJ904623 - Synthetic construct Homo sapiens clone ccsbBroadEn_14017 SEP15-like gene, encodes complete protein.
CU675093 - Synthetic construct Homo sapiens gateway clone IMAGE:100016722 5' read SEP15 mRNA.
JD040484 - Sequence 21508 from Patent EP1572962.
JD509444 - Sequence 490468 from Patent EP1572962.
JD131260 - Sequence 112284 from Patent EP1572962.
JD020261 - Sequence 1285 from Patent EP1572962.
JD035537 - Sequence 16561 from Patent EP1572962.
JD327065 - Sequence 308089 from Patent EP1572962.
JD079407 - Sequence 60431 from Patent EP1572962.
JD261933 - Sequence 242957 from Patent EP1572962.
KJ901971 - Synthetic construct Homo sapiens clone ccsbBroadEn_11365 SEP15 gene, encodes complete protein.
JD021622 - Sequence 2646 from Patent EP1572962.
JD336395 - Sequence 317419 from Patent EP1572962.
JD029065 - Sequence 10089 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_004261, O60613, Q4GZG7, Q8WU00, Q9BS64, Q9GZW0, Q9NR01, SEP15, SEP15_HUMAN, uc021oph.1, uc021oph.2, uc021oph.3
UCSC ID: uc021oph.3
RefSeq Accession: NM_004261
Protein: O60613 (aka SEP15_HUMAN)
CCDS: CCDS76178.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.