Human Gene SELENOF (ENST00000331835.10) Description and Page Index
  Description: Homo sapiens selenoprotein F (SELENOF), transcript variant 1, mRNA. (from RefSeq NM_004261)
RefSeq Summary (NM_004261): The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016].
Gencode Transcript: ENST00000331835.10
Gencode Gene: ENSG00000183291.17
Transcript (Including UTRs)
   Position: hg38 chr1:86,862,445-86,914,126 Size: 51,682 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr1:86,863,474-86,914,111 Size: 50,638 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:86,862,445-86,914,126)mRNA (may differ from genome)Protein (165 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SEP15_HUMAN
DESCRIPTION: RecName: Full=15 kDa selenoprotein; Flags: Precursor;
FUNCTION: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).
SUBUNIT: Forms a tight complex with UGGT1/UGCGL1 (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
TISSUE SPECIFICITY: Higher levels in prostate and thyroid gland.
PTM: The N-terminus is blocked.
MASS SPECTROMETRY: Mass=14870; Method=Electrospray; Range=26-162; Source=PubMed:9535873;
MASS SPECTROMETRY: Mass=14830; Method=MALDI; Range=26-162; Source=PubMed:9535873;
SIMILARITY: Belongs to the selenoprotein M/SEP15 family.
SEQUENCE CAUTION: Sequence=AAH05294.3; Type=Erroneous initiation; Sequence=AAH16359.3; Type=Erroneous initiation; Sequence=AAH21697.3; Type=Erroneous initiation;

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.19 RPKM in Cells - Cultured fibroblasts
Total median expression: 2253.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -201.901029-0.196 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014912 - Sep15_SelM
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF08806 - Sep15/SelM redox domain

ModBase Predicted Comparative 3D Structure on O60613
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051084 'de novo' posttranslational protein folding

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen


-  Descriptions from all associated GenBank mRNAs
  AK225640 - Homo sapiens mRNA for 15 kDa selenoprotein precursor variant, clone: SPL08543.
BC016359 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:24512 IMAGE:4096759), complete cds.
AF288991 - Homo sapiens 15 kDa selenoprotein (SEP15) mRNA, complete cds; alternatively spliced.
AK225252 - Homo sapiens mRNA for 15 kDa selenoprotein precursor variant, clone: DMC03465.
AL833575 - Homo sapiens mRNA; cDNA DKFZp686D2056 (from clone DKFZp686D2056).
AF051894 - Homo sapiens 15 kDa selenoprotein mRNA, complete cds.
BC005294 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:12358 IMAGE:4041321), complete cds.
BC021697 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:24367 IMAGE:4051151), complete cds.
KJ904623 - Synthetic construct Homo sapiens clone ccsbBroadEn_14017 SEP15-like gene, encodes complete protein.
CU675093 - Synthetic construct Homo sapiens gateway clone IMAGE:100016722 5' read SEP15 mRNA.
JD040484 - Sequence 21508 from Patent EP1572962.
JD509444 - Sequence 490468 from Patent EP1572962.
JD131260 - Sequence 112284 from Patent EP1572962.
JD020261 - Sequence 1285 from Patent EP1572962.
JD035537 - Sequence 16561 from Patent EP1572962.
JD327065 - Sequence 308089 from Patent EP1572962.
JD079407 - Sequence 60431 from Patent EP1572962.
JD261933 - Sequence 242957 from Patent EP1572962.
KJ901971 - Synthetic construct Homo sapiens clone ccsbBroadEn_11365 SEP15 gene, encodes complete protein.
JD021622 - Sequence 2646 from Patent EP1572962.
JD336395 - Sequence 317419 from Patent EP1572962.
JD029065 - Sequence 10089 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_004261, O60613, Q4GZG7, Q8WU00, Q9BS64, Q9GZW0, Q9NR01, SEP15, SEP15_HUMAN, uc021oph.1, uc021oph.2, uc021oph.3
UCSC ID: uc021oph.3
RefSeq Accession: NM_004261
Protein: O60613 (aka SEP15_HUMAN)
CCDS: CCDS76178.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.