Human Gene SELENOF (ENST00000331835.10) Description and Page Index
Description: Homo sapiens selenoprotein F (SELENOF), transcript variant 1, mRNA. (from RefSeq NM_004261) RefSeq Summary (NM_004261): The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]. Gencode Transcript: ENST00000331835.10 Gencode Gene: ENSG00000183291.17 Transcript (Including UTRs) Position: hg38 chr1:86,862,445-86,914,126 Size: 51,682 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr1:86,863,474-86,914,111 Size: 50,638 Coding Exon Count: 5
ID:SEP15_HUMAN DESCRIPTION: RecName: Full=15 kDa selenoprotein; Flags: Precursor; FUNCTION: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity). SUBUNIT: Forms a tight complex with UGGT1/UGCGL1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum. TISSUE SPECIFICITY: Higher levels in prostate and thyroid gland. PTM: The N-terminus is blocked. MASS SPECTROMETRY: Mass=14870; Method=Electrospray; Range=26-162; Source=PubMed:9535873; MASS SPECTROMETRY: Mass=14830; Method=MALDI; Range=26-162; Source=PubMed:9535873; SIMILARITY: Belongs to the selenoprotein M/SEP15 family. SEQUENCE CAUTION: Sequence=AAH05294.3; Type=Erroneous initiation; Sequence=AAH16359.3; Type=Erroneous initiation; Sequence=AAH21697.3; Type=Erroneous initiation;
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 84.19 RPKM in Cells - Cultured fibroblasts
Total median expression: 2253.18 RPKM
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60613
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.