Human Gene ADGRL2 (ENST00000370723.5) Description and Page Index
  Description: Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). (from UniProt O95490)
RefSeq Summary (NM_001366003): This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gencode Transcript: ENST00000370723.5
Gencode Gene: ENSG00000117114.19
Transcript (Including UTRs)
   Position: hg38 chr1:81,306,166-81,991,368 Size: 685,203 Total Exon Count: 25 Strand: +
Coding Region
   Position: hg38 chr1:81,836,985-81,991,145 Size: 154,161 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:81,306,166-81,991,368)mRNA (may differ from genome)Protein (1461 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneCardsHPRDLynxMGIneXtProt
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: LPHN2_HUMAN
DESCRIPTION: RecName: Full=Latrophilin-2; AltName: Full=Calcium-independent alpha-latrotoxin receptor 2; Short=CIRL-2; AltName: Full=Latrophilin homolog 1; AltName: Full=Lectomedin-1; Flags: Precursor;
FUNCTION: Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity).
SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.
PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SIMILARITY: Contains 1 olfactomedin-like domain.
SIMILARITY: Contains 1 SUEL-type lectin domain.
SEQUENCE CAUTION: Sequence=CAI22406.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPHH1ID313.html";

-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRL2
Diseases sorted by gene-association score: dermatophytosis (6)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.77 RPKM in Lung
Total median expression: 342.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -144.00645-0.223 Picture PostScript Text
3' UTR -41.30223-0.185 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022624 - DUF3497
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR003924 - GPCR_2_latrophilin
IPR003334 - GPCR_2_latrophilin_rcpt_C
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom
IPR000922 - Lectin_gal-bd_dom
IPR003112 - Olfac-like

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF12003 - n/a
PF02140 - Galactose binding lectin domain
PF01825 - GPCR proteolysis site, GPS, motif
PF02793 - Hormone receptor domain
PF02354 - Latrophilin Cytoplasmic C-terminal region
PF02191 - Olfactomedin-like domain

ModBase Predicted Comparative 3D Structure on O95490
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0016524 latrotoxin receptor activity
GO:0030246 carbohydrate binding

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK123422 - Homo sapiens cDNA FLJ41428 fis, clone BRHIP2005236, highly similar to Latrophilin-2 precursor.
AJ131581 - Homo sapiens mRNA for latrophilin-2.
BC031321 - Homo sapiens cDNA clone IMAGE:5284367.
AF104266 - Homo sapiens lectomedin-1 alpha (LEC1) mRNA, complete cds.
AF104938 - Homo sapiens lectomedin-1 beta (LEC1) mRNA, complete cds.
AF104939 - Homo sapiens lectomedin-1 gamma (LEC1) mRNA, complete cds.
BC172872 - Synthetic construct Homo sapiens clone IMAGE:9094448 latrophilin 2 precursor (LPHN2) gene, partial cds.
AB018329 - Homo sapiens mRNA for KIAA0786 protein, partial cds.
BC172873 - Synthetic construct Homo sapiens clone IMAGE:9094449 latrophilin 2 precursor (LPHN2) gene, partial cds.
DQ925675 - Homo sapiens clone 2-2 latrophilin 2 precursor (LPHN2) mRNA, partial cds, alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: A5XEI2, AJ131581, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, KIAA0786, LEC1, LPHH1, LPHN2, LPHN2_HUMAN, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6, uc009wce.1, uc009wce.2
UCSC ID: uc009wce.2
RefSeq Accession: NM_001366003
Protein: O95490 (aka LPHN2_HUMAN or LHN2_HUMAN)
CCDS: CCDS689.1, CCDS81345.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.