Human Gene ADGRL2 (ENST00000370730.5) Description and Page Index
Description: Homo sapiens adhesion G protein-coupled receptor L2 (ADGRL2), transcript variant 15, mRNA. (from RefSeq NM_001366009) RefSeq Summary (NM_001366003): This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000370730.5 Gencode Gene: ENSG00000117114.19 Transcript (Including UTRs) Position: hg38 chr1:81,306,166-81,992,422 Size: 686,257 Total Exon Count: 24 Strand: + Coding Region Position: hg38 chr1:81,836,985-81,991,145 Size: 154,161 Coding Exon Count: 20
ID:LPHN2_HUMAN DESCRIPTION: RecName: Full=Latrophilin-2; AltName: Full=Calcium-independent alpha-latrotoxin receptor 2; Short=CIRL-2; AltName: Full=Latrophilin homolog 1; AltName: Full=Lectomedin-1; Flags: Precursor; FUNCTION: Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 1 olfactomedin-like domain. SIMILARITY: Contains 1 SUEL-type lectin domain. SEQUENCE CAUTION: Sequence=CAI22406.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPHH1ID313.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95490
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.