Human Gene SELENOF (ENST00000616787.4) Description and Page Index
  Description: selenoprotein F (from HGNC SELENOF)
RefSeq Summary (NM_203341): The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016].
Gencode Transcript: ENST00000616787.4
Gencode Gene: ENSG00000183291.17
Transcript (Including UTRs)
   Position: hg38 chr1:86,862,447-86,914,424 Size: 51,978 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr1:86,863,474-86,914,111 Size: 50,638 Coding Exon Count: 6 

Page IndexSequence and LinksRNA-Seq ExpressionMicroarray ExpressionRNA StructureOther Species
mRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:86,862,447-86,914,424)mRNA (may differ from genome)Protein (164 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneCardsLynxMGIPubMedStanford SOURCE

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.19 RPKM in Cells - Cultured fibroblasts
Total median expression: 2253.18 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.20313-0.320 Picture PostScript Text
3' UTR -201.901027-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK225640 - Homo sapiens mRNA for 15 kDa selenoprotein precursor variant, clone: SPL08543.
BC016359 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:24512 IMAGE:4096759), complete cds.
AF288991 - Homo sapiens 15 kDa selenoprotein (SEP15) mRNA, complete cds; alternatively spliced.
AK225252 - Homo sapiens mRNA for 15 kDa selenoprotein precursor variant, clone: DMC03465.
AL833575 - Homo sapiens mRNA; cDNA DKFZp686D2056 (from clone DKFZp686D2056).
AF051894 - Homo sapiens 15 kDa selenoprotein mRNA, complete cds.
BC005294 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:12358 IMAGE:4041321), complete cds.
BC021697 - Homo sapiens 15 kDa selenoprotein, mRNA (cDNA clone MGC:24367 IMAGE:4051151), complete cds.
KJ904623 - Synthetic construct Homo sapiens clone ccsbBroadEn_14017 SEP15-like gene, encodes complete protein.
CU675093 - Synthetic construct Homo sapiens gateway clone IMAGE:100016722 5' read SEP15 mRNA.
JD040484 - Sequence 21508 from Patent EP1572962.
JD509444 - Sequence 490468 from Patent EP1572962.
JD131260 - Sequence 112284 from Patent EP1572962.
JD020261 - Sequence 1285 from Patent EP1572962.
JD035537 - Sequence 16561 from Patent EP1572962.
JD327065 - Sequence 308089 from Patent EP1572962.
JD079407 - Sequence 60431 from Patent EP1572962.
JD261933 - Sequence 242957 from Patent EP1572962.
KJ901971 - Synthetic construct Homo sapiens clone ccsbBroadEn_11365 SEP15 gene, encodes complete protein.
JD021622 - Sequence 2646 from Patent EP1572962.
JD336395 - Sequence 317419 from Patent EP1572962.
JD029065 - Sequence 10089 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087X1G7, BC016359, uc057ica.1
UCSC ID: uc057ica.1
RefSeq Accession: NM_203341
CCDS: CCDS76178.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.