Human Gene AMY2A (ENST00000414303.7) from GENCODE V44
Description: Homo sapiens amylase alpha 2A (AMY2A), mRNA. (from RefSeq NM_000699) RefSeq Summary (NM_000699): This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000414303.7 Gencode Gene: ENSG00000243480.8 Transcript (Including UTRs) Position: hg38 chr1:103,617,427-103,625,780 Size: 8,354 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr1:103,617,441-103,625,746 Size: 8,306 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04746
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P04746 (Reactome details) participates in the following event(s):
R-HSA-188979 Digestion of linear starch (amylose) by extracellular amylase R-HSA-191114 Digestion of branched starch (amylopectin) by extracellular amylase R-HSA-189085 Digestion of dietary carbohydrate R-HSA-8935690 Digestion R-HSA-8963743 Digestion and absorption
US Server
