Human Gene LGALS9 (ENST00000395473.7) from GENCODE V44
Description: Homo sapiens galectin 9 (LGALS9), transcript variant 1, mRNA. (from RefSeq NM_009587) RefSeq Summary (NM_009587): The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000395473.7 Gencode Gene: ENSG00000168961.17 Transcript (Including UTRs) Position: hg38 chr17:27,631,188-27,649,560 Size: 18,373 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr17:27,631,266-27,648,982 Size: 17,717 Coding Exon Count: 11
ID:LEG9_HUMAN DESCRIPTION: RecName: Full=Galectin-9; Short=Gal-9; AltName: Full=Ecalectin; AltName: Full=Tumor antigen HOM-HD-21; FUNCTION: Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. SUBUNIT: Monomer (Probable). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Secreted (By similarity). Note=May also be secreted by a non-classical secretory pathway (By similarity). TISSUE SPECIFICITY: Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue. DOMAIN: Contains two homologous but distinct carbohydrate-binding domains. SIMILARITY: Contains 2 galectin domains. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-9; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00120";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00182
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
