Human Gene CD28 (ENST00000324106.9) from GENCODE V44
Description: Homo sapiens CD28 molecule (CD28), transcript variant 1, mRNA. (from RefSeq NM_006139) RefSeq Summary (NM_006139): The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000324106.9 Gencode Gene: ENSG00000178562.18 Transcript (Including UTRs) Position: hg38 chr2:203,706,639-203,738,912 Size: 32,274 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr2:203,706,697-203,734,912 Size: 28,216 Coding Exon Count: 4
ID:CD28_HUMAN DESCRIPTION: RecName: Full=T-cell-specific surface glycoprotein CD28; AltName: Full=TP44; AltName: CD_antigen=CD28; Flags: Precursor; FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. SUBUNIT: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in T-cells and plasma cells, but not in less mature B-cells. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. WEB RESOURCE: Name=Wikipedia; Note=CD28 entry; URL="http://en.wikipedia.org/wiki/CD28";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10747
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002863 positive regulation of inflammatory response to antigenic stimulus GO:0006955 immune response GO:0006959 humoral immune response GO:0007166 cell surface receptor signaling pathway GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0031295 T cell costimulation GO:0032733 positive regulation of interleukin-10 production GO:0032753 positive regulation of interleukin-4 production GO:0042089 cytokine biosynthetic process GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0043066 negative regulation of apoptotic process GO:0045060 negative thymic T cell selection GO:0045066 regulatory T cell differentiation GO:0045070 positive regulation of viral genome replication GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045589 regulation of regulatory T cell differentiation GO:0045727 positive regulation of translation GO:0045840 positive regulation of mitotic nuclear division GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046641 positive regulation of alpha-beta T cell proliferation GO:0046854 phosphatidylinositol phosphorylation GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0050690 regulation of defense response to virus by virus GO:0050852 T cell receptor signaling pathway GO:0051897 positive regulation of protein kinase B signaling GO:0097190 apoptotic signaling pathway
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