Human Gene EP300 (ENST00000263253.9) from GENCODE V44
Description: Homo sapiens E1A binding protein p300 (EP300), transcript variant 1, mRNA. (from RefSeq NM_001429) RefSeq Summary (NM_001429): This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000263253.9 Gencode Gene: ENSG00000100393.15 Transcript (Including UTRs) Position: hg38 chr22:41,092,592-41,180,077 Size: 87,486 Total Exon Count: 31 Strand: + Coding Region Position: hg38 chr22:41,093,005-41,178,956 Size: 85,952 Coding Exon Count: 31
ID:EP300_HUMAN DESCRIPTION: RecName: Full=Histone acetyltransferase p300; Short=p300 HAT; EC=2.3.1.48; AltName: Full=E1A-associated protein p300; FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Interacts with phosphorylated CREB1 (By similarity). Interacts with HIF1A; the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the interaction requires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1 (unphosphorylated form preferentially and via C- terminus). Interacts with ESR1; the interaction is estrogen- dependent and enhanced by CITED1. Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, TP53, DDX5, DDX17, SATB1, SRCAP, TTC5, JMY and TRERF1. The TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5. Interacts with the C- terminal region of CITED4. Interacts with HTLV-1 Tax and p30II. Interacts with and acetylates HIV-1 Tat. Non-sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST. Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interaction is inhibited by NR0B2. Interacts with TCF3. Interacts (via CREB-binding domain) with MYOCD (via C-terminus) (By similarity). Binds to HIPK2 (By similarity). Interacts with ROCK2 and PPARG. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and this interaction enhances acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interaction acetylates FOXO1 and enhances its transcriptional activity. Interacts with DDIT3/CHOP. INTERACTION: P27695:APEX1; NbExp=6; IntAct=EBI-447295, EBI-1048805; Q9NPI1:BRD7; NbExp=3; IntAct=EBI-447295, EBI-711221; Q99967:CITED2; NbExp=3; IntAct=EBI-447295, EBI-937732; P17844:DDX5; NbExp=4; IntAct=EBI-447295, EBI-351962; Q16665:HIF1A; NbExp=5; IntAct=EBI-447295, EBI-447269; Q61221:Hif1a (xeno); NbExp=2; IntAct=EBI-447295, EBI-298954; Q9QXM1:Jmy (xeno); NbExp=16; IntAct=EBI-447295, EBI-866001; Q92831:KAT2B; NbExp=2; IntAct=EBI-447295, EBI-477430; P55209:NAP1L1; NbExp=3; IntAct=EBI-447295, EBI-356392; P20265:POU3F2; NbExp=3; IntAct=EBI-447295, EBI-1167176; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-447295, EBI-1802965; Q13309:SKP2; NbExp=3; IntAct=EBI-447295, EBI-456291; P05549:TFAP2A; NbExp=7; IntAct=EBI-447295, EBI-347351; P04637:TP53; NbExp=7; IntAct=EBI-447295, EBI-366083; P67809:YBX1; NbExp=2; IntAct=EBI-447295, EBI-354065; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Co-localizes with ROCK2 in the nucleus. DOMAIN: The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300 responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation and acetylation sites and the same lysine residues may be targeted for the respective modifications. It is proposed that deacetylation by SIRT1 allows sumoylation leading to suppressed activity. PTM: Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional repression domain (CRD1) by SIRT1, preferentially at Lys-1020. PTM: Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1. PTM: Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction with NCOA2/GRIP1. PTM: Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3. PTM: Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation. PTM: Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1 is associated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity. Phosphorylation at Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG. DISEASE: Note=Defects in EP300 may play a role in epithelial cancer. DISEASE: Note=Chromosomal aberrations involving EP300 may be a cause of acute myeloid leukemias. Translocation t(8;22)(p11;q13) with KAT6A. DISEASE: Defects in EP300 are the cause of Rubinstein-Taybi syndrome type 2 (RSTS2) [MIM:613684]. A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. Some individuals with RSTS2 have less severe mental impairment, more severe microcephaly, and a greater degree of changes in facial bone structure than RSTS1 patients. SIMILARITY: Contains 1 bromo domain. SIMILARITY: Contains 1 KIX domain. SIMILARITY: Contains 2 TAZ-type zinc fingers. SIMILARITY: Contains 1 ZZ-type zinc finger. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/P300ID97.html"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EP300"; WEB RESOURCE: Name=Wikipedia; Note=P300/CBP entry; URL="http://en.wikipedia.org/wiki/P300/CBP";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q09472
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001047 core promoter binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0002039 p53 binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003684 damaged DNA binding GO:0003712 transcription cofactor activity GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0005515 protein binding GO:0008013 beta-catenin binding GO:0008022 protein C-terminus binding GO:0008134 transcription factor binding GO:0008270 zinc ion binding GO:0016407 acetyltransferase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0031490 chromatin DNA binding GO:0033613 activating transcription factor binding GO:0034212 peptide N-acetyltransferase activity GO:0035257 nuclear hormone receptor binding GO:0046872 metal ion binding GO:0050681 androgen receptor binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0097157 pre-mRNA intronic binding GO:0097677 STAT family protein binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001666 response to hypoxia GO:0001756 somitogenesis GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0006283 transcription-coupled nucleotide-excision repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006915 apoptotic process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0007049 cell cycle GO:0007219 Notch signaling pathway GO:0007221 positive regulation of transcription of Notch receptor target GO:0007399 nervous system development GO:0007507 heart development GO:0007519 skeletal muscle tissue development GO:0007623 circadian rhythm GO:0009887 animal organ morphogenesis GO:0010506 regulation of autophagy GO:0010628 positive regulation of gene expression GO:0010742 macrophage derived foam cell differentiation GO:0016032 viral process GO:0016573 histone acetylation GO:0018076 N-terminal peptidyl-lysine acetylation GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0030183 B cell differentiation GO:0030220 platelet formation GO:0030324 lung development GO:0031648 protein destabilization GO:0032092 positive regulation of protein binding GO:0032460 negative regulation of protein oligomerization GO:0032481 positive regulation of type I interferon production GO:0034644 cellular response to UV GO:0035855 megakaryocyte development GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043627 response to estrogen GO:0043923 positive regulation by host of viral transcription GO:0043967 histone H4 acetylation GO:0043969 histone H2B acetylation GO:0045444 fat cell differentiation GO:0045652 regulation of megakaryocyte differentiation GO:0045747 positive regulation of Notch signaling pathway GO:0045815 positive regulation of gene expression, epigenetic GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048511 rhythmic process GO:0050821 protein stabilization GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051726 regulation of cell cycle GO:0060765 regulation of androgen receptor signaling pathway GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0090043 regulation of tubulin deacetylation GO:1900034 regulation of cellular response to heat GO:1901796 regulation of signal transduction by p53 class mediator GO:1904837 beta-catenin-TCF complex assembly
BioCarta from NCI Cancer Genome Anatomy Project h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1 h_il7Pathway - IL-7 Signal Transduction h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor h_melanocytepathway - Melanocyte Development and Pigmentation Pathway h_pelp1Pathway - Pelp1 Modulation of Estrogen Receptor Activity h_ppargPathway - Role of PPAR-gamma Coactivators in Obesity and Thermogenesis h_g2Pathway - Cell Cycle: G2/M Checkpoint h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System h_tgfbPathway - TGF beta signaling pathway h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2 h_vdrPathway - Control of Gene Expression by Vitamin D Receptor
Reactome (by CSHL, EBI, and GO)
Protein Q09472 (Reactome details) participates in the following event(s):
R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands R-HSA-1368087 RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene R-HSA-1912394 NICD1 in complex with RBPJ (CSL) recruits MAML R-HSA-2220964 NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML R-HSA-2976563 NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter R-HSA-3215152 TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter R-HSA-3222093 BRD7 binds TP53 and EP300 R-HSA-4088162 FOXM1 binds CDC25A promoter R-HSA-5250930 B-WICH recruits histone acetyltransferases R-HSA-5663246 RORA, EP300 bind NPAS2 gene R-HSA-5663264 RORA, EP300 bind CPT1A gene R-HSA-5663273 RORA, EP300, PPARGC1A bind NR1D1 gene R-HSA-5663293 RORA, EP300 bind SREBF1 gene R-HSA-6782004 Assembly of the pre-incision complex in TC-NER R-HSA-6804229 JMY, TTC5 and EP300 bind R-HSA-6811479 ING2 recruits EP300 to TP53 R-HSA-8864307 TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP R-HSA-8878056 RUNX1:CBFB binds EP300 R-HSA-8935740 RUNX1 and GATA1 bind the promoter of the ITGA2B gene R-HSA-8936616 RUNX1 and GATA1 bind the promoter of the GP1BA gene R-HSA-8936979 RUNX1 and GATA1 bind the promoter of the THBS1 gene R-HSA-8937037 RUNX1 and GATA1 bind the promoter of the MIR27A gene R-HSA-8951951 RUNX3 binds EP300 R-HSA-9008271 CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter R-HSA-9008285 NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter R-HSA-9011981 EP300 is recruited to MYC and BCL2 genes R-HSA-9018499 ESR1:ESTG and EP300 are recruited to TFF3 promoter R-HSA-9023840 HATs and coactivators are recruited to the CTSD gene R-HSA-9023884 NCOA1 recruits EP300 to TGFA promoter R-HSA-9038052 GREB1 binds ESR1:ESTG and co-activators R-HSA-1912391 NICD1 is phosphorylated by CDK8 R-NUL-2065178 CDK8 phosphorylates xNICD1 R-HSA-2220971 CDK8 phosphorylates NICD1 PEST domain mutants R-HSA-8952058 CCND1 binds RUNX3 and displaces EP300 R-HSA-1912393 MAML in complex with NICD1 recruits CDK8 R-HSA-4396347 NOTCH1 Coactivator Complex binds HES1 promoter R-HSA-4396371 NOTCH1 Coactivator Complex binds MYC promoter R-HSA-4396379 NOTCH1 Coactivator Complex binds HES5 promoter R-HSA-4396382 NOTCH1 Coactivator Complex binds promoters of HEY genes R-HSA-8878220 RUNX3 binds the NOTCH1 coactivator complex R-HSA-9017835 NOTCH1 coactivator complex binds NOTCH3 gene R-NUL-2064916 MAML recruits CDK8:CCNC to xNICD1 R-NUL-4396363 mNICD1 Chimeric Enhancer Complex binds Hes1 promoter R-HSA-2220957 NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC R-HSA-4396392 NOTCH1 PEST domain mutants bind HES1 promoter R-HSA-4396393 NOTCH1 PEST domain mutants bind MYC promoter R-HSA-4396401 NOTCH1 PEST domain mutants bind HES5 promoter R-HSA-4396402 NOTCH1 PEST domain mutants bind promoters of HEY genes R-HSA-6811508 ING2-bound EP300 acetylates TP53 R-HSA-5628871 BRD7 promotes EP300-mediated acetylation of TP53 R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6 R-HSA-6782131 RNA Pol II backtracking in TC-NER R-HSA-6782138 ERCC5 and RPA bind TC-NER site R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER R-HSA-6804242 TP53 binds the complex of JMY, EP300 and TTC5 R-HSA-8878050 HIPK2 phosphorylates RUNX1 and EP300 R-HSA-8951966 EP300 acetylates RUNX3 R-HSA-8951977 Acetylated RUNX3 binds to BRD2 R-HSA-933536 p-IRF7 dimer interacts with coactivator CBP/p300 R-HSA-1028817 CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 R-HSA-1028820 Formation of VAF (virus-activated factor) complex R-HSA-3134883 Beta-catenin enhances association of IRF3 with CBP/p300 R-HSA-3322427 Beta-catenin recruits CBP/p300 R-HSA-5660666 CBP and p300 binds NF-kB complex R-HSA-9023860 Histone acetyltransferases are recruited to the TFF1 gene R-HSA-3662335 EP300 acetylates histone H2A, H2B, H3, H4 R-HSA-8878237 RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter R-HSA-9021451 NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter R-HSA-6805650 MTA2-NuRD complex deacetylates TP53 R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER R-HSA-6804379 PRMT5 binds TTC5 R-HSA-6804383 PRMT5 methylates TP53 R-HSA-5691381 MYSM1 deubiquitinates Histone H2A R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter R-HSA-1028815 p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta R-HSA-5660660 p300 acetylates RELA subunit R-HSA-3371554 HSF1 acetylation at Lys80 R-HSA-8952081 RUNX proteins bind the p14-ARF promoter at the CDKN2A locus R-HSA-1028819 VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor R-HSA-400253 Circadian Clock R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2197563 NOTCH2 intracellular domain regulates transcription R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804758 Regulation of TP53 Activity through Acetylation R-HSA-156711 Polo-like kinase mediated events R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1368082 RORA activates gene expression R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-6804760 Regulation of TP53 Activity through Methylation R-HSA-6811555 PI5P Regulates TP53 Acetylation R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-9018519 Estrogen-dependent gene expression R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-1266738 Developmental Biology R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-1980145 Signaling by NOTCH2 R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-5633007 Regulation of TP53 Activity R-HSA-69275 G2/M Transition R-HSA-5250913 Positive epigenetic regulation of rRNA expression R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8878171 Transcriptional regulation by RUNX1 R-HSA-8878159 Transcriptional regulation by RUNX3 R-HSA-8939211 ESR-mediated signaling R-HSA-5696398 Nucleotide Excision Repair R-HSA-3214847 HATs acetylate histones R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription R-HSA-1912422 Pre-NOTCH Expression and Processing R-HSA-5689901 Metalloprotease DUBs R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-3371568 Attenuation phase R-HSA-2262749 Cellular response to hypoxia R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-453274 Mitotic G2-G2/M phases R-HSA-212165 Epigenetic regulation of gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-9006931 Signaling by Nuclear Receptors R-HSA-73894 DNA Repair R-HSA-3247509 Chromatin modifying enzymes R-HSA-9012852 Signaling by NOTCH3 R-HSA-5688426 Deubiquitination R-HSA-168249 Innate Immune System R-HSA-195721 Signaling by WNT R-HSA-3371571 HSF1-dependent transactivation R-HSA-2262752 Cellular responses to stress R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-69278 Cell Cycle (Mitotic) R-HSA-74160 Gene expression (Transcription) R-HSA-73857 RNA Polymerase II Transcription R-HSA-4839726 Chromatin organization R-HSA-597592 Post-translational protein modification R-HSA-168256 Immune System R-HSA-3371556 Cellular response to heat stress R-HSA-8953897 Cellular responses to external stimuli R-HSA-1643685 Disease R-HSA-1640170 Cell Cycle R-HSA-392499 Metabolism of proteins
US Server
