Human Gene ATAD3B (ENST00000308647.8) from GENCODE V44
  Description: ATPase family, AAA domain containing 3B (from HGNC ATAD3B)
RefSeq Summary (NM_031921): The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gencode Transcript: ENST00000308647.8
Gencode Gene: ENSG00000160072.20
Transcript (Including UTRs)
   Position: hg38 chr1:1,471,784-1,496,201 Size: 24,418 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg38 chr1:1,471,885-1,486,666 Size: 14,782 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,471,784-1,496,201)mRNA (may differ from genome)Protein (298 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGImyGene2PubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.96 RPKM in Pituitary
Total median expression: 550.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.70101-0.561 Picture PostScript Text
3' UTR -516.701119-0.462 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK290586 - Homo sapiens cDNA FLJ76112 complete cds, highly similar to Homo sapiens ATPase family, AAA domain containing 3B (ATAD3B),mRNA.
AK097309 - Homo sapiens cDNA FLJ39990 fis, clone STOMA2000686, highly similar to Homo sapiens TOB3 mRNA.
AF343078 - Homo sapiens TOB3 mRNA, complete cds.
BC002542 - Homo sapiens ATPase family, AAA domain containing 3B, mRNA (cDNA clone MGC:941 IMAGE:3138578), complete cds.
BC018701 - Homo sapiens ATPase family, AAA domain containing 3B, mRNA (cDNA clone MGC:15562 IMAGE:3139886), complete cds.
KJ899727 - Synthetic construct Homo sapiens clone ccsbBroadEn_09121 ATAD3B gene, encodes complete protein.
AK128357 - Homo sapiens cDNA FLJ46500 fis, clone THYMU3029719.
AB033099 - Homo sapiens mRNA for KIAA1273 protein, partial cds.
BC009938 - Homo sapiens ATPase family, AAA domain containing 3B, mRNA (cDNA clone IMAGE:4303497), with apparent retained intron.
AB384588 - Synthetic construct DNA, clone: pF1KA1273, Homo sapiens ATAD3B gene for ATPase family AAA domain-containing protein 3B, complete cds, without stop codon, in Flexi system.
KJ903364 - Synthetic construct Homo sapiens clone ccsbBroadEn_12758 ATAD3B gene, encodes complete protein.
AK024028 - Homo sapiens cDNA FLJ13966 fis, clone Y79AA1001394, weakly similar to CELL DIVISION PROTEIN FTSH HOMOLOG (EC 3.4.24.-).
AK127857 - Homo sapiens cDNA FLJ45960 fis, clone PLACE7012127, highly similar to Homo sapiens AAA-ATPase TOB3 (TOB3).
AL834179 - Homo sapiens mRNA; cDNA DKFZp761L1023 (from clone DKFZp761L1023).
JD328336 - Sequence 309360 from Patent EP1572962.
JD137118 - Sequence 118142 from Patent EP1572962.
JD205268 - Sequence 186292 from Patent EP1572962.
JD159732 - Sequence 140756 from Patent EP1572962.
JD159733 - Sequence 140757 from Patent EP1572962.
JD054415 - Sequence 35439 from Patent EP1572962.
JD335944 - Sequence 316968 from Patent EP1572962.
JD392738 - Sequence 373762 from Patent EP1572962.
JD399501 - Sequence 380525 from Patent EP1572962.
JD231512 - Sequence 212536 from Patent EP1572962.
JD217115 - Sequence 198139 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A5K1VW56, AK290586, ENST00000308647.1, ENST00000308647.2, ENST00000308647.3, ENST00000308647.4, ENST00000308647.5, ENST00000308647.6, ENST00000308647.7, uc001afv.1, uc001afv.2, uc001afv.3, uc001afv.4, uc001afv.5
UCSC ID: ENST00000308647.8
RefSeq Accession: NM_031921

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.