Human Gene TAS1R1 (ENST00000333172.11) from GENCODE V44
Description: Homo sapiens taste 1 receptor member 1 (TAS1R1), transcript variant 2, mRNA. (from RefSeq NM_138697) RefSeq Summary (NM_138697): The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000333172.11 Gencode Gene: ENSG00000173662.21 Transcript (Including UTRs) Position: hg38 chr1:6,555,307-6,579,755 Size: 24,449 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:6,555,374-6,579,584 Size: 24,211 Coding Exon Count: 6
ID:TS1R1_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 1 member 1; AltName: Full=G-protein coupled receptor 70; Flags: Precursor; FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. SEQUENCE CAUTION: Sequence=AAL91359.1; Type=Erroneous initiation; Sequence=AAL91360.1; Type=Erroneous initiation; Sequence=AAL91361.1; Type=Erroneous initiation; Sequence=BAC05845.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue 55 of February 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt055.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 - Receptor family ligand binding region PF07562 - Nine Cysteines Domain of family 3 GPCR
ModBase Predicted Comparative 3D Structure on Q7RTX1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC136515 - Homo sapiens taste receptor, type 1, member 1, mRNA (cDNA clone MGC:168128 IMAGE:9020505), complete cds. BC136516 - Homo sapiens taste receptor, type 1, member 1, mRNA (cDNA clone MGC:168129 IMAGE:9020506), complete cds. AK315805 - Homo sapiens cDNA, FLJ96929, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), mRNA. AK292014 - Homo sapiens cDNA FLJ77460 complete cds, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 3, mRNA. AK293499 - Homo sapiens cDNA FLJ52254 complete cds, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 3, mRNA. AF387618 - Homo sapiens gm148 form B mRNA, complete cds, alternatively spliced. AF387617 - Homo sapiens gm148 form A mRNA, complete cds, alternatively spliced. AF387619 - Homo sapiens gm148 form C mRNA, partial cds, alternatively spliced. AF387620 - Homo sapiens gm148 form D mRNA, partial cds, alternatively spliced. DQ592253 - Homo sapiens piRNA piR-59365, complete sequence. JD182763 - Sequence 163787 from Patent EP1572962. JD279242 - Sequence 260266 from Patent EP1572962. JD554767 - Sequence 535791 from Patent EP1572962. JD180944 - Sequence 161968 from Patent EP1572962. JD426036 - Sequence 407060 from Patent EP1572962. JD411119 - Sequence 392143 from Patent EP1572962. JD254260 - Sequence 235284 from Patent EP1572962. JD219206 - Sequence 200230 from Patent EP1572962. JD075277 - Sequence 56301 from Patent EP1572962. JD162932 - Sequence 143956 from Patent EP1572962. JD257835 - Sequence 238859 from Patent EP1572962. JD046289 - Sequence 27313 from Patent EP1572962. JD046290 - Sequence 27314 from Patent EP1572962. JD090542 - Sequence 71566 from Patent EP1572962. JD268044 - Sequence 249068 from Patent EP1572962. JD081458 - Sequence 62482 from Patent EP1572962. JD382260 - Sequence 363284 from Patent EP1572962. JD100257 - Sequence 81281 from Patent EP1572962. JD056793 - Sequence 37817 from Patent EP1572962. JD056794 - Sequence 37818 from Patent EP1572962. JD138900 - Sequence 119924 from Patent EP1572962. JD138901 - Sequence 119925 from Patent EP1572962. JD385290 - Sequence 366314 from Patent EP1572962. JD489953 - Sequence 470977 from Patent EP1572962. JD204991 - Sequence 186015 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04742 - Taste transduction
Reactome (by CSHL, EBI, and GO)
Protein Q7RTX1 (Reactome details) participates in the following event(s):
R-HSA-444705 T1R1/T1R3 dimer is the umami taste receptor R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
US Server
