Human Gene TNFRSF1B (ENST00000376259.7) from GENCODE V44
Description: Homo sapiens TNF receptor superfamily member 1B (TNFRSF1B), mRNA. (from RefSeq NM_001066) RefSeq Summary (NM_001066): The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000376259.7 Gencode Gene: ENSG00000028137.19 Transcript (Including UTRs) Position: hg38 chr1:12,166,991-12,209,220 Size: 42,230 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr1:12,167,092-12,207,020 Size: 39,929 Coding Exon Count: 10
ID:TNR1B_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 1B; AltName: Full=Tumor necrosis factor receptor 2; Short=TNF-R2; AltName: Full=Tumor necrosis factor receptor type II; Short=TNF-RII; Short=TNFR-II; AltName: Full=p75; AltName: Full=p80 TNF-alpha receptor; AltName: CD_antigen=CD120b; AltName: INN=Etanercept; Contains: RecName: Full=Tumor necrosis factor receptor superfamily member 1b, membrane form; Contains: RecName: Full=Tumor necrosis factor-binding protein 2; AltName: Full=TBP-2; AltName: Full=TBPII; Flags: Precursor; FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. SUBUNIT: Binds to TRAF2. Interacts with BMX. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted. PTM: Phosphorylated; mainly on serine residues and with a very low level on threonine residues. PTM: A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. PHARMACEUTICAL: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=Enbrel; Note=Clinical information on Enbrel; URL="http://www.enbrel.com/index.jspx";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20333
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.