Human Gene UBR4 (ENST00000375254.8) from GENCODE V44
Description: Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA. (from RefSeq NM_020765) RefSeq Summary (NM_020765): The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]. Gencode Transcript: ENST00000375254.8 Gencode Gene: ENSG00000127481.15 Transcript (Including UTRs) Position: hg38 chr1:19,074,510-19,210,266 Size: 135,757 Total Exon Count: 106 Strand: - Coding Region Position: hg38 chr1:19,074,832-19,210,248 Size: 135,417 Coding Exon Count: 106
ID:UBR4_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase UBR4; EC=6.3.2.-; AltName: Full=600 kDa retinoblastoma protein-associated factor; AltName: Full=N-recognin-4; AltName: Full=Retinoblastoma-associated factor of 600 kDa; Short=RBAF600; Short=p600; AltName: Full=Zinc finger UBR1-type protein 1; FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11. INTERACTION: Q96EZ8:MCRS1; NbExp=1; IntAct=EBI-1995940, EBI-348259; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility. SIMILARITY: Belongs to the UBR4 family. SIMILARITY: Contains 1 UBR-type zinc finger. SEQUENCE CAUTION: Sequence=CAD43719.1; Type=Erroneous initiation; Sequence=CAI19271.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T4S7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0016032 viral process GO:0016567 protein ubiquitination GO:0043312 neutrophil degranulation
AB007931 - Homo sapiens mRNA for KIAA0462 protein, partial cds. AF348492 - Homo sapiens p600 mRNA, complete cds. AK000331 - Homo sapiens cDNA FLJ20324 fis, clone HEP09841, highly similar to AB007931 Homo sapiens mRNA for KIAA0462 protein. AK092390 - Homo sapiens cDNA FLJ35071 fis, clone PLACE6000191. AX747516 - Sequence 1041 from Patent EP1308459. BC018694 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 4, mRNA (cDNA clone IMAGE:3506191), partial cds. BC073905 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 4, mRNA (cDNA clone IMAGE:4451241), partial cds. BC063573 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 4, mRNA (cDNA clone IMAGE:3875762), partial cds. AJ505016 - Homo sapiens mRNA for retinoblastoma-associated factor 600-like protein (RBAF600 gene), mutant allele. AK025149 - Homo sapiens cDNA: FLJ21496 fis, clone COL05623. AK022924 - Homo sapiens cDNA FLJ12862 fis, clone NT2RP2003567, highly similar to Homo sapiens mRNA for KIAA0462 protein. AK298314 - Homo sapiens cDNA FLJ53474 complete cds, highly similar to Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA. AK123857 - Homo sapiens cDNA FLJ41863 fis, clone OCBBF1000315. AK026543 - Homo sapiens cDNA: FLJ22890 fis, clone KAT04573, highly similar to AF055010 Homo sapiens clone 24561 unknown mRNA. AF055010 - Homo sapiens clone 24561 unknown mRNA, partial cds. AK125800 - Homo sapiens cDNA FLJ43812 fis, clone TESTI4001206. AK022573 - Homo sapiens cDNA FLJ12511 fis, clone NT2RM2001727, highly similar to Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA. AK023826 - Homo sapiens cDNA FLJ13764 fis, clone PLACE4000106, highly similar to Homo sapiens mRNA for KIAA0462 protein. BC007962 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 4, mRNA (cDNA clone IMAGE:4301372), partial cds. AL049972 - Homo sapiens mRNA; cDNA DKFZp564B122 (from clone DKFZp564B122). BC096758 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 4, mRNA (cDNA clone IMAGE:4849875), partial cds. AK001233 - Homo sapiens cDNA FLJ10371 fis, clone NT2RM2001903, highly similar to Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA. JD190461 - Sequence 171485 from Patent EP1572962. JD394892 - Sequence 375916 from Patent EP1572962. JD334994 - Sequence 316018 from Patent EP1572962. JD389851 - Sequence 370875 from Patent EP1572962. JD281890 - Sequence 262914 from Patent EP1572962. JD431735 - Sequence 412759 from Patent EP1572962. AK302623 - Homo sapiens cDNA FLJ53484 complete cds, highly similar to Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA. JD253624 - Sequence 234648 from Patent EP1572962. JD324575 - Sequence 305599 from Patent EP1572962. JD442403 - Sequence 423427 from Patent EP1572962. JD447801 - Sequence 428825 from Patent EP1572962. JD022678 - Sequence 3702 from Patent EP1572962. JD019647 - Sequence 671 from Patent EP1572962. AK022322 - Homo sapiens cDNA FLJ12260 fis, clone MAMMA1001551. DL491421 - Novel nucleic acids. DL490043 - Novel nucleic acids. AK056218 - Homo sapiens cDNA FLJ31656 fis, clone NT2RI2004290, weakly similar to Drosophila melanogaster mRNA for calossin protein. AB037728 - Homo sapiens mRNA for KIAA1307 protein, partial cds. BC015865 - Homo sapiens zinc finger, UBR1 type 1, mRNA (cDNA clone IMAGE:4691776). BC041137 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 4, mRNA (cDNA clone IMAGE:5226385), with apparent retained intron.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q5T4S7 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-6798747 Exocytosis of tertiary granule membrane proteins R-HSA-6799350 Exocytosis of specific granule membrane proteins R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-6798695 Neutrophil degranulation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-168249 Innate Immune System R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System