Human Gene MRTO4 (ENST00000330263.5) from GENCODE V44
  Description: Homo sapiens MRT4 homolog, ribosome maturation factor (MRTO4), mRNA. (from RefSeq NM_016183)
RefSeq Summary (NM_016183): This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000330263.5
Gencode Gene: ENSG00000053372.5
Transcript (Including UTRs)
   Position: hg38 chr1:19,251,805-19,260,128 Size: 8,324 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr1:19,251,836-19,258,830 Size: 6,995 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:19,251,805-19,260,128)mRNA (may differ from genome)Protein (239 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MRT4_HUMAN
DESCRIPTION: RecName: Full=mRNA turnover protein 4 homolog;
FUNCTION: Involved in mRNA turnover and ribosome assembly (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the ribosomal protein L10P family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.93 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 620.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.6031-0.213 Picture PostScript Text
3' UTR -566.101298-0.436 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001790 - Ribosomal_L10/acidic_P0

Pfam Domains:
PF00466 - Ribosomal protein L10

ModBase Predicted Comparative 3D Structure on Q9UKD2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000027 ribosomal large subunit assembly
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF206694 - JP 2014500723-A/14197: Polycomb-Associated Non-Coding RNAs.
MA442271 - JP 2018138019-A/14197: Polycomb-Associated Non-Coding RNAs.
AK027569 - Homo sapiens cDNA FLJ14663 fis, clone NT2RP2002862, weakly similar to 60S ACIDIC RIBOSOMAL PROTEIN P0.
AF173378 - Homo sapiens 60S acidic ribosomal protein PO mRNA, complete cds.
BC003013 - Homo sapiens mRNA turnover 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4041 IMAGE:2821148), complete cds.
BC006504 - Homo sapiens mRNA turnover 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:2400 IMAGE:2821148), complete cds.
AK024227 - Homo sapiens cDNA FLJ14165 fis, clone NT2RP1000746, highly similar to mRNA turnover protein 4 homolog.
AY303790 - Homo sapiens acidic ribosomal protein PO-like mRNA, complete cds.
AK126387 - Homo sapiens cDNA FLJ44423 fis, clone UTERU2004929.
KJ898840 - Synthetic construct Homo sapiens clone ccsbBroadEn_08234 MRTO4 gene, encodes complete protein.
AK295328 - Homo sapiens cDNA FLJ57985 complete cds, moderately similar to mRNA turnover protein 4 homolog.
LF357175 - JP 2014500723-A/164678: Polycomb-Associated Non-Coding RNAs.
MA592752 - JP 2018138019-A/164678: Polycomb-Associated Non-Coding RNAs.
JD343016 - Sequence 324040 from Patent EP1572962.
JD170697 - Sequence 151721 from Patent EP1572962.
JD488035 - Sequence 469059 from Patent EP1572962.
LF357174 - JP 2014500723-A/164677: Polycomb-Associated Non-Coding RNAs.
MA592751 - JP 2018138019-A/164677: Polycomb-Associated Non-Coding RNAs.
JD438277 - Sequence 419301 from Patent EP1572962.
LF357173 - JP 2014500723-A/164676: Polycomb-Associated Non-Coding RNAs.
MA592750 - JP 2018138019-A/164676: Polycomb-Associated Non-Coding RNAs.
JD140108 - Sequence 121132 from Patent EP1572962.
JD144650 - Sequence 125674 from Patent EP1572962.
JD542687 - Sequence 523711 from Patent EP1572962.
JD212653 - Sequence 193677 from Patent EP1572962.
JD212652 - Sequence 193676 from Patent EP1572962.
JD198029 - Sequence 179053 from Patent EP1572962.
JD198028 - Sequence 179052 from Patent EP1572962.
JD413319 - Sequence 394343 from Patent EP1572962.
JD413318 - Sequence 394342 from Patent EP1572962.
JD246800 - Sequence 227824 from Patent EP1572962.
JD246802 - Sequence 227826 from Patent EP1572962.
JD246804 - Sequence 227828 from Patent EP1572962.
JD246805 - Sequence 227829 from Patent EP1572962.
JD171558 - Sequence 152582 from Patent EP1572962.
JD101825 - Sequence 82849 from Patent EP1572962.
JD277875 - Sequence 258899 from Patent EP1572962.
JD430358 - Sequence 411382 from Patent EP1572962.
JD430359 - Sequence 411383 from Patent EP1572962.
JD529491 - Sequence 510515 from Patent EP1572962.
JD529492 - Sequence 510516 from Patent EP1572962.
JD529493 - Sequence 510517 from Patent EP1572962.
JD169792 - Sequence 150816 from Patent EP1572962.
JD169794 - Sequence 150818 from Patent EP1572962.
JD306432 - Sequence 287456 from Patent EP1572962.
JD055296 - Sequence 36320 from Patent EP1572962.
JD395512 - Sequence 376536 from Patent EP1572962.
JD531857 - Sequence 512881 from Patent EP1572962.
JD176516 - Sequence 157540 from Patent EP1572962.
JD066731 - Sequence 47755 from Patent EP1572962.
JD184047 - Sequence 165071 from Patent EP1572962.
JD092608 - Sequence 73632 from Patent EP1572962.
JD559989 - Sequence 541013 from Patent EP1572962.
JD539776 - Sequence 520800 from Patent EP1572962.
JD470338 - Sequence 451362 from Patent EP1572962.
JD439068 - Sequence 420092 from Patent EP1572962.
JD482605 - Sequence 463629 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KNB3, C1orf33, ENST00000330263.1, ENST00000330263.2, ENST00000330263.3, ENST00000330263.4, MRT4, MRT4_HUMAN, NM_016183, Q5TG55, Q96SS6, Q9BPV9, Q9UKD2, uc001bbs.1, uc001bbs.2, uc001bbs.3, uc001bbs.4, uc001bbs.5
UCSC ID: ENST00000330263.5
RefSeq Accession: NM_016183
Protein: Q9UKD2 (aka MRT4_HUMAN)
CCDS: CCDS191.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.