Human Gene DNAJC8 (ENST00000263697.6) Description and Page Index
  Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member C8 (DNAJC8), transcript variant 1, mRNA. (from RefSeq NM_014280)
Gencode Transcript: ENST00000263697.6
Gencode Gene: ENSG00000126698.11
Transcript (Including UTRs)
   Position: hg38 chr1:28,200,278-28,233,029 Size: 32,752 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr1:28,201,248-28,232,998 Size: 31,751 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:28,200,278-28,233,029)mRNA (may differ from genome)Protein (253 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 8; AltName: Full=Splicing protein spf31;
SIMILARITY: Contains 1 J domain.
SEQUENCE CAUTION: Sequence=AAC35352.1; Type=Erroneous initiation; Sequence=CAG33181.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.44 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1016.55 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.5031-0.210 Picture PostScript Text
3' UTR -277.30970-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR003095 - Hsp_DnaJ

Pfam Domains:
PF00226 - DnaJ domain

ModBase Predicted Comparative 3D Structure on O75937
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030544 Hsp70 protein binding

Biological Process:
GO:0000398 mRNA splicing, via spliceosome

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0045171 intercellular bridge

-  Descriptions from all associated GenBank mRNAs
  AF161449 - Homo sapiens HSPC331 mRNA, partial cds.
AF161433 - Homo sapiens HSPC315 mRNA, partial cds.
BC033159 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 8, mRNA (cDNA clone MGC:45787 IMAGE:4330676), complete cds.
AF083190 - Homo sapiens SPF31 (SPF31) mRNA, complete cds.
BX538122 - Homo sapiens mRNA; cDNA DKFZp686P08160 (from clone DKFZp686P08160).
JD377546 - Sequence 358570 from Patent EP1572962.
JD454939 - Sequence 435963 from Patent EP1572962.
JD271151 - Sequence 252175 from Patent EP1572962.
JD203190 - Sequence 184214 from Patent EP1572962.
JD043041 - Sequence 24065 from Patent EP1572962.
JD289226 - Sequence 270250 from Patent EP1572962.
AK300797 - Homo sapiens cDNA FLJ61418 complete cds, highly similar to DnaJ homolog subfamily C member 8.
JD121389 - Sequence 102413 from Patent EP1572962.
JD252010 - Sequence 233034 from Patent EP1572962.
JD259825 - Sequence 240849 from Patent EP1572962.
JD189370 - Sequence 170394 from Patent EP1572962.
JD288879 - Sequence 269903 from Patent EP1572962.
JD390949 - Sequence 371973 from Patent EP1572962.
JD392905 - Sequence 373929 from Patent EP1572962.
JD554856 - Sequence 535880 from Patent EP1572962.
JD102498 - Sequence 83522 from Patent EP1572962.
JD381133 - Sequence 362157 from Patent EP1572962.
JD230510 - Sequence 211534 from Patent EP1572962.
JD180990 - Sequence 162014 from Patent EP1572962.
KJ898410 - Synthetic construct Homo sapiens clone ccsbBroadEn_07804 DNAJC8 gene, encodes complete protein.
CR456900 - Homo sapiens full open reading frame cDNA clone RZPDo834B047D for gene DNAJC8, DnaJ (Hsp40) homolog, subfamily C, member 8; complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75937 (Reactome details) participates in the following event(s):

R-HSA-72124 Formation of the Spliceosomal A Complex
R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage
R-HSA-72139 Formation of the active Spliceosomal C (B*) complex
R-HSA-72127 Formation of the Spliceosomal B Complex
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex
R-HSA-156661 Formation of Exon Junction Complex
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: B4DUU4, D3DPM0, DNJC8_HUMAN, HSPC315, HSPC331, NM_014280, O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067, SPF31, uc001bpn.1, uc001bpn.2, uc001bpn.3, uc001bpn.4, uc001bpn.5
UCSC ID: uc001bpn.5
RefSeq Accession: NM_014280
Protein: O75937 (aka DNJC8_HUMAN or DJC8_HUMAN)
CCDS: CCDS41292.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.