Human Gene DNAJC8 (ENST00000263697.6) Description and Page Index
Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member C8 (DNAJC8), transcript variant 1, mRNA. (from RefSeq NM_014280)
Gencode Transcript: ENST00000263697.6
Gencode Gene: ENSG00000126698.11
Transcript (Including UTRs)
Position: hg38 chr1:28,200,278-28,233,029 Size: 32,752 Total Exon Count: 9 Strand: -
Position: hg38 chr1:28,201,248-28,232,998 Size: 31,751 Coding Exon Count: 9
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 8; AltName: Full=Splicing protein spf31;
SIMILARITY: Contains 1 J domain. SEQUENCE CAUTION: Sequence=AAC35352.1; Type=Erroneous initiation; Sequence=CAG33181.1; Type=Erroneous initiation;
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001623 - DnaJ_N
IPR003095 - Hsp_DnaJ
Pfam Domains: PF00226 - DnaJ domain
ModBase Predicted Comparative 3D Structure on O75937
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF161449 - Homo sapiens HSPC331 mRNA, partial cds. AF161433 - Homo sapiens HSPC315 mRNA, partial cds. BC033159 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 8, mRNA (cDNA clone MGC:45787 IMAGE:4330676), complete cds. AF083190 - Homo sapiens SPF31 (SPF31) mRNA, complete cds. BX538122 - Homo sapiens mRNA; cDNA DKFZp686P08160 (from clone DKFZp686P08160). JD377546 - Sequence 358570 from Patent EP1572962. JD454939 - Sequence 435963 from Patent EP1572962. JD271151 - Sequence 252175 from Patent EP1572962. JD203190 - Sequence 184214 from Patent EP1572962. JD043041 - Sequence 24065 from Patent EP1572962. JD289226 - Sequence 270250 from Patent EP1572962. AK300797 - Homo sapiens cDNA FLJ61418 complete cds, highly similar to DnaJ homolog subfamily C member 8. JD121389 - Sequence 102413 from Patent EP1572962. JD252010 - Sequence 233034 from Patent EP1572962. JD259825 - Sequence 240849 from Patent EP1572962. JD189370 - Sequence 170394 from Patent EP1572962. JD288879 - Sequence 269903 from Patent EP1572962. JD390949 - Sequence 371973 from Patent EP1572962. JD392905 - Sequence 373929 from Patent EP1572962. JD554856 - Sequence 535880 from Patent EP1572962. JD102498 - Sequence 83522 from Patent EP1572962. JD381133 - Sequence 362157 from Patent EP1572962. JD230510 - Sequence 211534 from Patent EP1572962. JD180990 - Sequence 162014 from Patent EP1572962. KJ898410 - Synthetic construct Homo sapiens clone ccsbBroadEn_07804 DNAJC8 gene, encodes complete protein. CR456900 - Homo sapiens full open reading frame cDNA clone RZPDo834B047D for gene DNAJC8, DnaJ (Hsp40) homolog, subfamily C, member 8; complete cds, incl. stopcodon.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B4DUU4, D3DPM0, DNJC8_HUMAN, HSPC315, HSPC331, NM_014280, O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067, SPF31, uc001bpn.1, uc001bpn.2, uc001bpn.3, uc001bpn.4, uc001bpn.5 UCSC ID: uc001bpn.5 RefSeq Accession: NM_014280
(aka DNJC8_HUMAN or DJC8_HUMAN) O75937
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.