Human Gene NDUFS5 (ENST00000372967.3) from GENCODE V44
  Description: NADH:ubiquinone oxidoreductase subunit S5 (from HGNC NDUFS5)
RefSeq Summary (NM_001184979): This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010].
Gencode Transcript: ENST00000372967.3
Gencode Gene: ENSG00000168653.11
Transcript (Including UTRs)
   Position: hg38 chr1:39,026,318-39,034,636 Size: 8,319 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr1:39,028,725-39,034,496 Size: 5,772 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:39,026,318-39,034,636)mRNA (may differ from genome)Protein (106 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NDUFS5
Diseases sorted by gene-association score: mitochondrial complex i deficiency (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 424.43 RPKM in Heart - Left Ventricle
Total median expression: 9891.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.2083-0.255 Picture PostScript Text
3' UTR -25.50140-0.182 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019342 - NADH_UbQ_OxRdtase_FeS-su5

Pfam Domains:
PF10200 - NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

ModBase Predicted Comparative 3D Structure on Q6IBA0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK312188 - Homo sapiens cDNA, FLJ92475, Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa(NADH-coenzyme Q reductase) (NDUFS5), mRNA.
AF047434 - Homo sapiens NADH-ubiquinone oxidoreductase 15kDa subunit mRNA, complete cds.
BC093057 - Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase), mRNA (cDNA clone MGC:111140 IMAGE:30382835), complete cds.
AF020352 - Homo sapiens NADH:ubiquinone oxidoreductase 15 kDa IP subunit mRNA, nuclear gene encoding mitochondrial protein, complete cds.
AF086268 - Homo sapiens full length insert cDNA clone ZD43H11.
BC001884 - Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase), mRNA (cDNA clone MGC:1496 IMAGE:3544747), complete cds.
KJ891682 - Synthetic construct Homo sapiens clone ccsbBroadEn_01076 NDUFS5 gene, encodes complete protein.
JF432447 - Synthetic construct Homo sapiens clone IMAGE:100073657 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) (NDUFS5) gene, encodes complete protein.
CR456904 - Homo sapiens full open reading frame cDNA clone RZPDo834C057D for gene NDUFS5, NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase); complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: AF047434, ENST00000372967.1, ENST00000372967.2, hCG_1782706, Q6IBA0, Q6IBA0_HUMAN, RP11-781D11.3-001, uc001ccy.1, uc001ccy.2, uc001ccy.3, uc001ccy.4
UCSC ID: ENST00000372967.3
RefSeq Accession: NM_001184979
Protein: Q6IBA0 CCDS: CCDS434.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.