Human Gene HPCAL4 (ENST00000372844.8) Description and Page Index
Description: Homo sapiens hippocalcin like 4 (HPCAL4), transcript variant 1, mRNA. (from RefSeq NM_016257) RefSeq Summary (NM_016257): The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000372844.8 Gencode Gene: ENSG00000116983.13 Transcript (Including UTRs) Position: hg38 chr1:39,678,648-39,691,433 Size: 12,786 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr1:39,682,536-39,684,603 Size: 2,068 Coding Exon Count: 3
ID:HPCL4_HUMAN DESCRIPTION: RecName: Full=Hippocalcin-like protein 4; Short=HLP4; FUNCTION: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation (By similarity). MISCELLANEOUS: Probably binds two or three calcium ions (By similarity). SIMILARITY: Belongs to the recoverin family. SIMILARITY: Contains 4 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UM19
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.