Human Gene ZNF644 (ENST00000337393.10) from GENCODE V44
Description: Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 1, mRNA. (from RefSeq NM_201269) RefSeq Summary (NM_201269): The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000337393.10 Gencode Gene: ENSG00000122482.22 Transcript (Including UTRs) Position: hg38 chr1:90,915,304-91,022,035 Size: 106,732 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:90,916,798-90,982,353 Size: 65,556 Coding Exon Count: 5
ID:ZN644_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 644; AltName: Full=Zinc finger motif enhancer-binding protein 2; Short=Zep-2; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in liver, placenta, retina and retinal pigment epithelium. DISEASE: Defects in ZNF644 are the cause of myopia type 21 (MYP21) [MIM:614167]. A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 7 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H582
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter
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