Human Gene TSPAN2 (ENST00000369516.7) from GENCODE V44
Description: Homo sapiens tetraspanin 2 (TSPAN2), transcript variant 1, mRNA. (from RefSeq NM_005725) RefSeq Summary (NM_005725): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Gencode Transcript: ENST00000369516.7 Gencode Gene: ENSG00000134198.10 Transcript (Including UTRs) Position: hg38 chr1:115,048,011-115,089,503 Size: 41,493 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr1:115,050,490-115,089,432 Size: 38,943 Coding Exon Count: 8
ID:TSN2_HUMAN DESCRIPTION: RecName: Full=Tetraspanin-2; Short=Tspan-2; AltName: Full=Tetraspan NET-3; FUNCTION: May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60636
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
