Human Gene TRIM45 (ENST00000256649.9) from GENCODE V44
Description: Homo sapiens tripartite motif containing 45 (TRIM45), transcript variant 1, mRNA. (from RefSeq NM_025188) RefSeq Summary (NM_025188): This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000256649.9 Gencode Gene: ENSG00000134253.10 Transcript (Including UTRs) Position: hg38 chr1:117,111,060-117,121,749 Size: 10,690 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:117,112,305-117,121,201 Size: 8,897 Coding Exon Count: 6
ID:TRI45_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 45; AltName: Full=RING finger protein 99; FUNCTION: May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in skeletal muscle, brain, heart and pancreas. DEVELOPMENTAL STAGE: Expressed in brain, lung, skeletal muscle, heart and intestine in 80-day old embryo. SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 2 B box-type zinc fingers. SIMILARITY: Contains 1 filamin repeat. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H8W5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.