ID:OTU7B_HUMAN DESCRIPTION: RecName: Full=OTU domain-containing protein 7B; EC=3.4.19.12; AltName: Full=Cellular zinc finger anti-NF-kappa-B protein; AltName: Full=Zinc finger A20 domain-containing protein 1; AltName: Full=Zinc finger protein Cezanne; FUNCTION: Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SUBUNIT: Interacts with TRAF6. INTERACTION: Q8IVM0:CCDC50; NbExp=5; IntAct=EBI-527784, EBI-723996; Q99497:PARK7; NbExp=3; IntAct=EBI-527784, EBI-1164361; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. SIMILARITY: Belongs to the peptidase C64 family. SIMILARITY: Contains 1 A20-type zinc finger. SIMILARITY: Contains 1 OTU domain. SEQUENCE CAUTION: Sequence=CAB97494.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6GQQ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0005515 protein binding GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0046872 metal ion binding GO:0070530 K63-linked polyubiquitin binding GO:1990380 Lys48-specific deubiquitinase activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002250 adaptive immune response GO:0002376 immune system process GO:0002385 mucosal immune response GO:0006508 proteolysis GO:0006955 immune response GO:0016579 protein deubiquitination GO:0032717 negative regulation of interleukin-8 production GO:0035871 protein K11-linked deubiquitination GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0070536 protein K63-linked deubiquitination GO:0071108 protein K48-linked deubiquitination GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:1900181 negative regulation of protein localization to nucleus
US Server
