Human Gene RAB13 (ENST00000368575.5) from GENCODE V44
Description: Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript variant 3, non-coding RNA. (from RefSeq NR_073553) RefSeq Summary (NM_002870): This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]. Gencode Transcript: ENST00000368575.5 Gencode Gene: ENSG00000143545.10 Transcript (Including UTRs) Position: hg38 chr1:153,981,650-153,986,339 Size: 4,690 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr1:153,982,099-153,986,236 Size: 4,138 Coding Exon Count: 8
ID:RAB13_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-13; AltName: Full=Cell growth-inhibiting gene 4 protein; Flags: Precursor; FUNCTION: Could participate in polarized transport, in the assembly and/or the activity of tight junctions. SUBUNIT: Interacts with CCDC64B/BICDR2 (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. TISSUE SPECIFICITY: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51153
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0010737 protein kinase A signaling GO:0015031 protein transport GO:0016197 endosomal transport GO:0030866 cortical actin cytoskeleton organization GO:0031175 neuron projection development GO:0032456 endocytic recycling GO:0032869 cellular response to insulin stimulus GO:0035767 endothelial cell chemotaxis GO:0043687 post-translational protein modification GO:0044795 trans-Golgi network to recycling endosome transport GO:0070830 bicellular tight junction assembly GO:0072659 protein localization to plasma membrane GO:0097368 establishment of Sertoli cell barrier GO:1902463 protein localization to cell leading edge