Human Gene DCST2 (ENST00000368424.4) from GENCODE V44
  Description: Homo sapiens DC-STAMP domain containing 2 (DCST2), mRNA. (from RefSeq NM_144622)
Gencode Transcript: ENST00000368424.4
Gencode Gene: ENSG00000163354.15
Transcript (Including UTRs)
   Position: hg38 chr1:155,018,527-155,033,781 Size: 15,255 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg38 chr1:155,018,544-155,033,701 Size: 15,158 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:155,018,527-155,033,781)mRNA (may differ from genome)Protein (773 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=DC-STAMP domain-containing protein 2;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=BAC05065.1; Type=Frameshift; Positions=736;

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.31 RPKM in Testis
Total median expression: 76.53 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.9080-0.224 Picture PostScript Text
3' UTR -1.2017-0.071 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012858 - DC_STAMP-like

Pfam Domains:
PF07782 - DC-STAMP-like protein

ModBase Predicted Comparative 3D Structure on Q5T1A1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  LF206184 - JP 2014500723-A/13687: Polycomb-Associated Non-Coding RNAs.
MA441761 - JP 2018138019-A/13687: Polycomb-Associated Non-Coding RNAs.
AK057496 - Homo sapiens cDNA FLJ32934 fis, clone TESTI2007480.
AK097993 - Homo sapiens cDNA FLJ40674 fis, clone THYMU2021684.
AK097468 - Homo sapiens cDNA FLJ40149 fis, clone TESTI2013671.
BC166652 - Synthetic construct Homo sapiens clone IMAGE:100066378, MGC:195515 DC-STAMP domain containing 2 (DCST2) mRNA, encodes complete protein.
JD099535 - Sequence 80559 from Patent EP1572962.
JD147814 - Sequence 128838 from Patent EP1572962.
JD131902 - Sequence 112926 from Patent EP1572962.
JD372149 - Sequence 353173 from Patent EP1572962.
JD058574 - Sequence 39598 from Patent EP1572962.
BC111794 - Homo sapiens DC-STAMP domain containing 2, mRNA (cDNA clone IMAGE:40026521), partial cds.
JD370356 - Sequence 351380 from Patent EP1572962.
JD484782 - Sequence 465806 from Patent EP1572962.
JD368694 - Sequence 349718 from Patent EP1572962.
JD532880 - Sequence 513904 from Patent EP1572962.
JD484781 - Sequence 465805 from Patent EP1572962.
LF352230 - JP 2014500723-A/159733: Polycomb-Associated Non-Coding RNAs.
MA587807 - JP 2018138019-A/159733: Polycomb-Associated Non-Coding RNAs.
JD256432 - Sequence 237456 from Patent EP1572962.
JD292680 - Sequence 273704 from Patent EP1572962.
JD156264 - Sequence 137288 from Patent EP1572962.
JD400567 - Sequence 381591 from Patent EP1572962.
JD411483 - Sequence 392507 from Patent EP1572962.
JD132719 - Sequence 113743 from Patent EP1572962.
JD144918 - Sequence 125942 from Patent EP1572962.
JD396936 - Sequence 377960 from Patent EP1572962.
JD400420 - Sequence 381444 from Patent EP1572962.
JD422552 - Sequence 403576 from Patent EP1572962.
JD374083 - Sequence 355107 from Patent EP1572962.
JD204672 - Sequence 185696 from Patent EP1572962.
JD514343 - Sequence 495367 from Patent EP1572962.
JD067511 - Sequence 48535 from Patent EP1572962.
JD313489 - Sequence 294513 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DCST2_HUMAN, ENST00000368424.1, ENST00000368424.2, ENST00000368424.3, NM_144622, Q2M2R2, Q5T1A1, Q8N810, Q96M03, uc001fgm.1, uc001fgm.2, uc001fgm.3, uc001fgm.4, uc001fgm.5
UCSC ID: ENST00000368424.4
RefSeq Accession: NM_144622
Protein: Q5T1A1 (aka DCST2_HUMAN)
CCDS: CCDS1082.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.