Human Gene MEX3A (ENST00000532414.3) from GENCODE V44
  Description: Homo sapiens mex-3 RNA binding family member A (MEX3A), mRNA. (from RefSeq NM_001093725)
Gencode Transcript: ENST00000532414.3
Gencode Gene: ENSG00000254726.3
Transcript (Including UTRs)
   Position: hg38 chr1:156,072,013-156,082,465 Size: 10,453 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:156,076,574-156,081,998 Size: 5,425 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:156,072,013-156,082,465)mRNA (may differ from genome)Protein (520 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MEX3A_HUMAN
DESCRIPTION: RecName: Full=RNA-binding protein MEX3A; AltName: Full=RING finger and KH domain-containing protein 4;
FUNCTION: RNA binding protein, may be involved in post- transcriptional regulatory mechanisms.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.
TISSUE SPECIFICITY: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.
DOMAIN: Binds RNA through its KH domains (By similarity).
PTM: Phosphorylated.
SIMILARITY: Contains 2 KH domains.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MEX3A
Diseases sorted by gene-association score: wilson-turner syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.90 RPKM in Ovary
Total median expression: 22.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -229.60467-0.492 Picture PostScript Text
3' UTR -1668.804561-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004087 - KH_dom
IPR004088 - KH_dom_type_1
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00013 - KH domain

ModBase Predicted Comparative 3D Structure on A1L020
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0046872 metal ion binding

Cellular Component:
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC033283 - Homo sapiens cDNA clone IMAGE:4933522, partial cds.
JD438807 - Sequence 419831 from Patent EP1572962.
AK095491 - Homo sapiens cDNA FLJ38172 fis, clone FCBBF1000038.
AK024097 - Homo sapiens cDNA FLJ14035 fis, clone HEMBA1004638.
AK125482 - Homo sapiens cDNA FLJ43493 fis, clone OCBBF3009279.
JD460600 - Sequence 441624 from Patent EP1572962.
JD470751 - Sequence 451775 from Patent EP1572962.
JD266355 - Sequence 247379 from Patent EP1572962.
JD440139 - Sequence 421163 from Patent EP1572962.
JD178114 - Sequence 159138 from Patent EP1572962.
JD304535 - Sequence 285559 from Patent EP1572962.
JD302667 - Sequence 283691 from Patent EP1572962.
JD316000 - Sequence 297024 from Patent EP1572962.
JD063558 - Sequence 44582 from Patent EP1572962.
JD213485 - Sequence 194509 from Patent EP1572962.
JD143186 - Sequence 124210 from Patent EP1572962.
JD506795 - Sequence 487819 from Patent EP1572962.
JD504505 - Sequence 485529 from Patent EP1572962.
JD399041 - Sequence 380065 from Patent EP1572962.
JD220589 - Sequence 201613 from Patent EP1572962.
JD039638 - Sequence 20662 from Patent EP1572962.
JD253528 - Sequence 234552 from Patent EP1572962.
JD402299 - Sequence 383323 from Patent EP1572962.
JD077203 - Sequence 58227 from Patent EP1572962.
JD449680 - Sequence 430704 from Patent EP1572962.
JD207271 - Sequence 188295 from Patent EP1572962.
JD400739 - Sequence 381763 from Patent EP1572962.
JD120098 - Sequence 101122 from Patent EP1572962.
JD459056 - Sequence 440080 from Patent EP1572962.
JD117674 - Sequence 98698 from Patent EP1572962.
JD189328 - Sequence 170352 from Patent EP1572962.
JD218255 - Sequence 199279 from Patent EP1572962.
JD486028 - Sequence 467052 from Patent EP1572962.
JD099718 - Sequence 80742 from Patent EP1572962.
JD171613 - Sequence 152637 from Patent EP1572962.
JD134605 - Sequence 115629 from Patent EP1572962.
JD475021 - Sequence 456045 from Patent EP1572962.
JD502783 - Sequence 483807 from Patent EP1572962.
JD480091 - Sequence 461115 from Patent EP1572962.
JD179654 - Sequence 160678 from Patent EP1572962.
JD149959 - Sequence 130983 from Patent EP1572962.
JD545875 - Sequence 526899 from Patent EP1572962.
JD351359 - Sequence 332383 from Patent EP1572962.
JD392766 - Sequence 373790 from Patent EP1572962.
JD402291 - Sequence 383315 from Patent EP1572962.
JD403535 - Sequence 384559 from Patent EP1572962.
JD127641 - Sequence 108665 from Patent EP1572962.
JD272220 - Sequence 253244 from Patent EP1572962.
JD520233 - Sequence 501257 from Patent EP1572962.
JD054960 - Sequence 35984 from Patent EP1572962.
JD405924 - Sequence 386948 from Patent EP1572962.
JD264988 - Sequence 246012 from Patent EP1572962.
JD048270 - Sequence 29294 from Patent EP1572962.
JD240622 - Sequence 221646 from Patent EP1572962.
JD366094 - Sequence 347118 from Patent EP1572962.
JD327504 - Sequence 308528 from Patent EP1572962.
JD446144 - Sequence 427168 from Patent EP1572962.
JD481693 - Sequence 462717 from Patent EP1572962.
JD484123 - Sequence 465147 from Patent EP1572962.
JD485389 - Sequence 466413 from Patent EP1572962.
JD336903 - Sequence 317927 from Patent EP1572962.
JD417202 - Sequence 398226 from Patent EP1572962.
AY950677 - Homo sapiens MEX3A mRNA, complete cds.
JD320137 - Sequence 301161 from Patent EP1572962.
JD239165 - Sequence 220189 from Patent EP1572962.
JD387438 - Sequence 368462 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1L020, ENST00000532414.1, ENST00000532414.2, MEX3A_HUMAN, NM_001093725, RKHD4, uc001fnd.1, uc001fnd.2, uc001fnd.3, uc001fnd.4, uc001fnd.5
UCSC ID: ENST00000532414.3
RefSeq Accession: NM_001093725
Protein: A1L020 (aka MEX3A_HUMAN)
CCDS: CCDS53377.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.