Human Gene SH2D2A (ENST00000368199.8) from GENCODE V44
Description: Homo sapiens SH2 domain containing 2A (SH2D2A), transcript variant 2, mRNA. (from RefSeq NM_003975) RefSeq Summary (NM_003975): This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Gencode Transcript: ENST00000368199.8 Gencode Gene: ENSG00000027869.12 Transcript (Including UTRs) Position: hg38 chr1:156,806,243-156,816,848 Size: 10,606 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr1:156,807,178-156,816,708 Size: 9,531 Coding Exon Count: 8
ID:SH22A_HUMAN DESCRIPTION: RecName: Full=SH2 domain-containing protein 2A; AltName: Full=SH2 domain-containing adapter protein; AltName: Full=T cell-specific adapter protein; Short=TSAd; AltName: Full=VEGF receptor-associated protein; FUNCTION: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. SUBUNIT: Interacts with KDR. Interacts with TXK and ITK (By similarity). SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver. INDUCTION: Rapidly induced after activation of T-cells. However, the gene continues to be expressed in long-term cultures of activated T-cells. PTM: Phosphorylated on tyrosine residues. SIMILARITY: Contains 1 SH2 domain. SEQUENCE CAUTION: Sequence=AAC99298.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NP31
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
