Human Gene FCRL4 (ENST00000271532.2) from GENCODE V44
Description: Homo sapiens Fc receptor like 4 (FCRL4), mRNA. (from RefSeq NM_031282) RefSeq Summary (NM_031282): This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]. Gencode Transcript: ENST00000271532.2 Gencode Gene: ENSG00000163518.11 Transcript (Including UTRs) Position: hg38 chr1:157,573,747-157,598,085 Size: 24,339 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr1:157,575,524-157,597,944 Size: 22,421 Coding Exon Count: 12
ID:FCRL4_HUMAN DESCRIPTION: RecName: Full=Fc receptor-like protein 4; Short=FcR-like protein 4; Short=FcRL4; AltName: Full=Fc receptor homolog 4; Short=FcRH4; AltName: Full=IFGP family protein 2; Short=hIFGP2; AltName: Full=Immune receptor translocation-associated protein 1; AltName: CD_antigen=CD307d; Flags: Precursor; FUNCTION: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. INTERACTION: P04155:TFF1; NbExp=3; IntAct=EBI-4314687, EBI-743871; Q03403:TFF2; NbExp=3; IntAct=EBI-4314687, EBI-4314702; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level). PTM: Phosphorylated on cytoplasmic tyrosines upon activation. DISEASE: Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). DISEASE: Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. SIMILARITY: Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96PJ5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
