Human Gene FCRL2 (ENST00000361516.8) from GENCODE V44
  Description: Homo sapiens Fc receptor like 2 (FCRL2), transcript variant 1, mRNA. (from RefSeq NM_030764)
RefSeq Summary (NM_030764): This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009].
Gencode Transcript: ENST00000361516.8
Gencode Gene: ENSG00000132704.16
Transcript (Including UTRs)
   Position: hg38 chr1:157,745,733-157,777,132 Size: 31,400 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr1:157,746,736-157,777,073 Size: 30,338 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:157,745,733-157,777,132)mRNA (may differ from genome)Protein (508 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Fc receptor-like protein 2; Short=FcR-like protein 2; Short=FcRL2; AltName: Full=Fc receptor homolog 2; Short=FcRH2; AltName: Full=IFGP family protein 4; AltName: Full=Immunoglobulin receptor translocation-associated protein 4; AltName: Full=SH2 domain-containing phosphatase anchor protein 1; AltName: CD_antigen=CD307b; Flags: Precursor;
FUNCTION: May have an regulatory role in normal and neoplastic B cell development.
SUBUNIT: The tyrosine-phosphorylated isoform 2 interacts with PTPN6.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B- cell lines. Preferentially expressed in memory B-cells (at protein level).
DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.
PTM: Isoform 2 is N- and O-glycosylated, and phosphorylated.
SIMILARITY: Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: FCRL2
Diseases sorted by gene-association score: chronic lymphocytic leukemia (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.53 RPKM in Spleen
Total median expression: 43.04 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.0059-0.271 Picture PostScript Text
3' UTR -261.001003-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR003598 - Ig_sub2

ModBase Predicted Comparative 3D Structure on Q96LA5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding

Biological Process:
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction

Cellular Component:
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AL833361 - Homo sapiens mRNA; cDNA DKFZp667E1614 (from clone DKFZp667E1614).
AL833194 - Homo sapiens mRNA; cDNA DKFZp667P075 (from clone DKFZp667P075).
AF459633 - Homo sapiens immunoglobulin superfamily receptor translocation associated 4 mRNA, complete cds.
BC069185 - Homo sapiens Fc receptor-like 2, mRNA (cDNA clone IMAGE:6714138), complete cds.
AY043465 - Homo sapiens Fc receptor-like protein 2 (FCRH2) mRNA, complete cds.
JD503007 - Sequence 484031 from Patent EP1572962.
JD305066 - Sequence 286090 from Patent EP1572962.
JD088517 - Sequence 69541 from Patent EP1572962.
JD156895 - Sequence 137919 from Patent EP1572962.
JD530702 - Sequence 511726 from Patent EP1572962.
AY358130 - Homo sapiens clone DNA182432 FcRH2 (UNQ9236) mRNA, complete cds.
AF319438 - Homo sapiens SH2 domain-containing phosphatase anchor protein 1a (SPAP1) mRNA, complete cds, alternatively spliced.
BC129836 - Homo sapiens Fc receptor-like 2, mRNA (cDNA clone MGC:149464 IMAGE:40115446), complete cds.
AF390037 - Homo sapiens IFGP4 mRNA, complete cds.
AK301113 - Homo sapiens cDNA FLJ57824 complete cds, highly similar to Fc receptor-like protein 2 precursor.
KJ903169 - Synthetic construct Homo sapiens clone ccsbBroadEn_12563 FCRL2 gene, encodes complete protein.
CU686705 - Synthetic construct Homo sapiens gateway clone IMAGE:100023152 5' read FCRL2 mRNA.
KJ903168 - Synthetic construct Homo sapiens clone ccsbBroadEn_12562 FCRL2 gene, encodes complete protein.
AF319439 - Homo sapiens SH2 domain-containing phosphatase anchor protein 1b (SPAP1) mRNA, complete cds, alternatively spliced.
AF319440 - Homo sapiens SH2 domain-containing phosphatase anchor protein 1c (SPAP1) mRNA, complete cds, alternatively spliced.
JD372738 - Sequence 353762 from Patent EP1572962.
AK303549 - Homo sapiens cDNA FLJ59003 complete cds, highly similar to Fc receptor-like protein 2 precursor.

-  Other Names for This Gene
  Alternate Gene Symbols: A0N0M5, A1L307, A6NMS0, ENST00000361516.1, ENST00000361516.2, ENST00000361516.3, ENST00000361516.4, ENST00000361516.5, ENST00000361516.6, ENST00000361516.7, FCRH2, FCRL2_HUMAN, IFGP4, IRTA4, NM_030764, Q6NTA1, Q96LA5, Q9BZI4, Q9BZI5, Q9BZI6, SPAP1, uc001fre.1, uc001fre.2, uc001fre.3, uc001fre.4, UNQ9236/PRO31998
UCSC ID: ENST00000361516.8
RefSeq Accession: NM_030764
Protein: Q96LA5 (aka FCRL2_HUMAN)
CCDS: CCDS1168.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.