Human Gene ATP6V1G3 (ENST00000281087.6) from GENCODE V44
Description: Homo sapiens ATPase H+ transporting V1 subunit G3 (ATP6V1G3), transcript variant 1, mRNA. (from RefSeq NM_133262) RefSeq Summary (NM_133262): This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000281087.6 Gencode Gene: ENSG00000151418.12 Transcript (Including UTRs) Position: hg38 chr1:198,523,224-198,540,945 Size: 17,722 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr1:198,523,391-198,540,650 Size: 17,260 Coding Exon Count: 3
ID:VATG3_HUMAN DESCRIPTION: RecName: Full=V-type proton ATPase subunit G 3; Short=V-ATPase subunit G 3; AltName: Full=V-ATPase 13 kDa subunit 3; AltName: Full=Vacuolar proton pump subunit G 3; FUNCTION: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) (By similarity). TISSUE SPECIFICITY: Kidney. SIMILARITY: Belongs to the V-ATPase G subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03179 - Vacuolar (H+)-ATPase G subunit
ModBase Predicted Comparative 3D Structure on Q96LB4
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0051117 ATPase binding
Biological Process: GO:0006811 ion transport GO:0008286 insulin receptor signaling pathway GO:0033572 transferrin transport GO:0034220 ion transmembrane transport GO:1902600 hydrogen ion transmembrane transport