Human Gene TRAF5 (ENST00000336184.6) from GENCODE V44
Description: Homo sapiens TNF receptor associated factor 5 (TRAF5), transcript variant 1, mRNA. (from RefSeq NM_004619) RefSeq Summary (NM_004619): The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000336184.6 Gencode Gene: ENSG00000082512.15 Transcript (Including UTRs) Position: hg38 chr1:211,326,615-211,374,940 Size: 48,326 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr1:211,353,240-211,372,702 Size: 19,463 Coding Exon Count: 10
ID:TRAF5_HUMAN DESCRIPTION: RecName: Full=TNF receptor-associated factor 5; AltName: Full=RING finger protein 84; FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. SUBUNIT: Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. INTERACTION: Q92956:TNFRSF14; NbExp=5; IntAct=EBI-523498, EBI-1056653; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood. DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains. SIMILARITY: Belongs to the TNF receptor-associated factor family. A subfamily. SIMILARITY: Contains 1 MATH domain. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 2 TRAF-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00917 - MATH domain PF00097 - Zinc finger, C3HC4 type (RING finger)
ModBase Predicted Comparative 3D Structure on O00463
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0007165 signal transduction GO:0042981 regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity