Human Gene INTS7 (ENST00000366994.8) from GENCODE V44
Description: Homo sapiens integrator complex subunit 7 (INTS7), transcript variant 1, mRNA. (from RefSeq NM_015434) RefSeq Summary (NM_015434): This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000366994.8 Gencode Gene: ENSG00000143493.13 Transcript (Including UTRs) Position: hg38 chr1:211,940,403-212,035,557 Size: 95,155 Total Exon Count: 20 Strand: - Coding Region Position: hg38 chr1:211,941,824-212,035,437 Size: 93,614 Coding Exon Count: 20
ID:INT7_HUMAN DESCRIPTION: RecName: Full=Integrator complex subunit 7; Short=Int7; FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. SUBUNIT: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2. SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner. SIMILARITY: Belongs to the Integrator subunit 7 family. SEQUENCE CAUTION: Sequence=BAA91650.1; Type=Erroneous termination; Positions=618; Note=Translated as Cys; Sequence=BAB14116.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NVH2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.