Human Gene KCNK2 (ENST00000391894.6) from GENCODE V44
  Description: Homo sapiens potassium two pore domain channel subfamily K member 2 (KCNK2), transcript variant 2, mRNA. (from RefSeq NM_014217)
RefSeq Summary (NM_014217): This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000391894.6
Gencode Gene: ENSG00000082482.14
Transcript (Including UTRs)
   Position: hg38 chr1:215,083,124-215,235,217 Size: 152,094 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr1:215,083,307-215,235,145 Size: 151,839 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:215,083,124-215,235,217)mRNA (may differ from genome)Protein (411 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KCNK2
Diseases sorted by gene-association score: dentin sensitivity (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.41 RPKM in Cells - Cultured fibroblasts
Total median expression: 108.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.60183-0.211 Picture PostScript Text
3' UTR -13.8072-0.192 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AY552981 - Homo sapiens tandem-pore-domain potassium channel TREK-1 splice variant e mRNA, complete cds.
AK123409 - Homo sapiens cDNA FLJ41415 fis, clone BRHIP2001805, moderately similar to Homo sapiens TREK-1 potassium channel (KCNK2) mRNA.
AY552980 - Homo sapiens tandem-pore-domain potassium channel TREK-1 splice variant c mRNA, complete cds.
KF182338 - Homo sapiens potassium channel subfamily k member 2 variant 1 (KCNK2) mRNA, complete cds.
AK315249 - Homo sapiens cDNA, FLJ96253, Homo sapiens potassium channel, subfamily K, member 2 (KCNK2),mRNA.
AK294780 - Homo sapiens cDNA FLJ58876 complete cds, highly similar to Potassium channel subfamily K member 2.
AK291483 - Homo sapiens cDNA FLJ75204 complete cds, highly similar to Homo sapiens two-pore potassium channel TPKC1 mRNA.
BC143586 - Homo sapiens potassium channel, subfamily K, member 2, mRNA (cDNA clone MGC:177114 IMAGE:9052097), complete cds.
BC101693 - Homo sapiens potassium channel, subfamily K, member 2, mRNA (cDNA clone MGC:126742 IMAGE:8069199), complete cds.
BC101695 - Homo sapiens potassium channel, subfamily K, member 2, mRNA (cDNA clone MGC:126744 IMAGE:8069201), complete cds.
AF004711 - Homo sapiens two-pore potassium channel TPKC1 mRNA, complete cds.
EF165334 - Homo sapiens tissue-type brain K2P2.1 potassium channel (KCNK2) mRNA, complete cds.
KF182339 - Homo sapiens potassium channel subfamily k member 2 variant 2 (KCNK2) mRNA, complete cds.
AF171068 - Homo sapiens two-pore domain potassium channel TREK-1 (TREK-1) mRNA, complete cds.
BC069462 - Homo sapiens potassium channel, subfamily K, member 2, mRNA (cDNA clone MGC:97115 IMAGE:7262344), complete cds.
EF165335 - Homo sapiens tissue-type heart K2P2.1 potassium channel (KCNK2) mRNA, complete cds.
KJ891505 - Synthetic construct Homo sapiens clone ccsbBroadEn_00899 KCNK2 gene, encodes complete protein.
AF129399 - Homo sapiens TREK-1 potassium channel (KCNK2) mRNA, complete cds.
JD313120 - Sequence 294144 from Patent EP1572962.
JD429516 - Sequence 410540 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000391894.1, ENST00000391894.2, ENST00000391894.3, ENST00000391894.4, ENST00000391894.5, NM_014217, U3N6F0, uc001hkr.1, uc001hkr.2, uc001hkr.3, uc001hkr.4, uc001hkr.5
UCSC ID: ENST00000391894.6
RefSeq Accession: NM_014217
CCDS: CCDS41467.1, CCDS31024.1, CCDS41466.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.