Human Gene DIP2C (ENST00000280886.12) from GENCODE V44
  Description: Homo sapiens disco interacting protein 2 homolog C (DIP2C), mRNA. (from RefSeq NM_014974)
RefSeq Summary (NM_014974): This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008].
Gencode Transcript: ENST00000280886.12
Gencode Gene: ENSG00000151240.18
Transcript (Including UTRs)
   Position: hg38 chr10:274,201-689,668 Size: 415,468 Total Exon Count: 37 Strand: -
Coding Region
   Position: hg38 chr10:277,325-689,578 Size: 412,254 Coding Exon Count: 37 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:274,201-689,668)mRNA (may differ from genome)Protein (1556 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGImyGene2
neXtProtOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DIP2C_HUMAN
DESCRIPTION: RecName: Full=Disco-interacting protein 2 homolog C; Short=DIP2 homolog C;
SIMILARITY: Belongs to the DIP2 family.
SEQUENCE CAUTION: Sequence=BAA76778.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.74 RPKM in Colon - Sigmoid
Total median expression: 287.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.4090-0.527 Picture PostScript Text
3' UTR -883.103124-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000873 - AMP-dep_Synth/Lig
IPR010506 - DMAP1-bd

Pfam Domains:
PF00501 - AMP-binding enzyme
PF06464 - DMAP1-binding Domain

ModBase Predicted Comparative 3D Structure on Q9Y2E4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003824 catalytic activity

Biological Process:
GO:0008150 biological_process
GO:0008152 metabolic process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AB023151 - Homo sapiens KIAA0934 mRNA for KIAA0934 protein.
BC063313 - Homo sapiens DIP2 disco-interacting protein 2 homolog C (Drosophila), mRNA (cDNA clone MGC:71829 IMAGE:30349267), complete cds.
AB384049 - Synthetic construct DNA, clone: pF1KSDA0934, Homo sapiens DIP2C gene for disco-interacting protein 2 homolog C, complete cds, without stop codon, in Flexi system.
AK126063 - Homo sapiens cDNA FLJ44075 fis, clone TESTI4038339, highly similar to Disco-interacting protein 2 homolog C.
AK310613 - Homo sapiens cDNA, FLJ17655.
AX803815 - Sequence 11 from Patent WO03060129.
BC035216 - Homo sapiens DIP2 disco-interacting protein 2 homolog C (Drosophila), mRNA (cDNA clone IMAGE:4748955).
BX537672 - Homo sapiens mRNA; cDNA DKFZp686J01130 (from clone DKFZp686J01130).
JD346342 - Sequence 327366 from Patent EP1572962.
JD550697 - Sequence 531721 from Patent EP1572962.
JD347514 - Sequence 328538 from Patent EP1572962.
JD158592 - Sequence 139616 from Patent EP1572962.
JD124083 - Sequence 105107 from Patent EP1572962.
JD461487 - Sequence 442511 from Patent EP1572962.
JD338093 - Sequence 319117 from Patent EP1572962.
JD198553 - Sequence 179577 from Patent EP1572962.
JD289121 - Sequence 270145 from Patent EP1572962.
DQ600361 - Homo sapiens piRNA piR-38427, complete sequence.
JD298742 - Sequence 279766 from Patent EP1572962.
JD469746 - Sequence 450770 from Patent EP1572962.
JD298798 - Sequence 279822 from Patent EP1572962.
AK311679 - Homo sapiens cDNA, FLJ18721.
JD171069 - Sequence 152093 from Patent EP1572962.
BC048327 - Homo sapiens DIP2 disco-interacting protein 2 homolog C (Drosophila), mRNA (cDNA clone IMAGE:5163354), partial cds.
AK093390 - Homo sapiens cDNA FLJ36071 fis, clone TESTI2019501.
AK309715 - Homo sapiens cDNA, FLJ99756.
JD073733 - Sequence 54757 from Patent EP1572962.
JD456361 - Sequence 437385 from Patent EP1572962.
AX803822 - Sequence 18 from Patent WO03060129.
JD229494 - Sequence 210518 from Patent EP1572962.
JD554377 - Sequence 535401 from Patent EP1572962.
AX803814 - Sequence 10 from Patent WO03060129.
AX803813 - Sequence 9 from Patent WO03060129.
AX803816 - Sequence 12 from Patent WO03060129.
AX803812 - Sequence 8 from Patent WO03060129.
AK310018 - Homo sapiens cDNA, FLJ17060.
AX803818 - Sequence 14 from Patent WO03060129.
MP015017 - Sequence 220 from Patent WO2019016252.
AK298353 - Homo sapiens cDNA FLJ50825 complete cds, highly similar to Disco-interacting protein 2 homolog C.
AX803824 - Sequence 20 from Patent WO03060129.
AX803819 - Sequence 15 from Patent WO03060129.
AX803825 - Sequence 21 from Patent WO03060129.

-  Other Names for This Gene
  Alternate Gene Symbols: DIP2C_HUMAN, ENST00000280886.1, ENST00000280886.10, ENST00000280886.11, ENST00000280886.2, ENST00000280886.3, ENST00000280886.4, ENST00000280886.5, ENST00000280886.6, ENST00000280886.7, ENST00000280886.8, ENST00000280886.9, KIAA0934, NM_014974, Q5SS78, Q9Y2E4, uc001ifp.1, uc001ifp.2, uc001ifp.3, uc001ifp.4, uc001ifp.5, uc001ifp.6
UCSC ID: ENST00000280886.12
RefSeq Accession: NM_014974
Protein: Q9Y2E4 (aka DIP2C_HUMAN)
CCDS: CCDS7054.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.