Human Gene IDI2 (ENST00000277517.2) from GENCODE V44
Description: Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA. (from RefSeq NM_033261) RefSeq Summary (NM_033261): The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENST00000277517.2 Gencode Gene: ENSG00000148377.6 Transcript (Including UTRs) Position: hg38 chr10:1,018,910-1,025,859 Size: 6,950 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr10:1,019,517-1,024,723 Size: 5,207 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BXS1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004452 isopentenyl-diphosphate delta-isomerase activity GO:0016787 hydrolase activity GO:0016853 isomerase activity GO:0046872 metal ion binding
Biological Process: GO:0006629 lipid metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008299 isoprenoid biosynthetic process GO:0009240 isopentenyl diphosphate biosynthetic process GO:0016126 sterol biosynthetic process GO:0046490 isopentenyl diphosphate metabolic process GO:0050992 dimethylallyl diphosphate biosynthetic process
US Server
