Human Gene CALML3 (ENST00000315238.3) from GENCODE V44
  Description: Homo sapiens calmodulin like 3 (CALML3), mRNA. (from RefSeq NM_005185)
Gencode Transcript: ENST00000315238.3
Gencode Gene: ENSG00000178363.5
Transcript (Including UTRs)
   Position: hg38 chr10:5,524,961-5,526,771 Size: 1,811 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr10:5,525,086-5,525,535 Size: 450 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:5,524,961-5,526,771)mRNA (may differ from genome)Protein (149 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Calmodulin-like protein 3; AltName: Full=CaM-like protein; Short=CLP; AltName: Full=Calmodulin-related protein NB-1;
FUNCTION: May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates.
TISSUE SPECIFICITY: Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.
MISCELLANEOUS: Binds four calcium ions.
SIMILARITY: Belongs to the calmodulin family.
SIMILARITY: Contains 4 EF-hand domains.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 668.44 RPKM in Esophagus - Mucosa
Total median expression: 1456.27 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.80125-0.366 Picture PostScript Text
3' UTR -479.601236-0.388 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018248 - EF-hand
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

Pfam Domains:
PF00036 - EF hand

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GGZ - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P27482
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Cellular Component:
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  DQ891776 - Synthetic construct clone IMAGE:100004406; FLH179825.01X; RZPDo839C02132D calmodulin-like 3 (CALML3) gene, encodes complete protein.
DQ894960 - Synthetic construct Homo sapiens clone IMAGE:100009420; FLH179821.01L; RZPDo839C02131D calmodulin-like 3 (CALML3) gene, encodes complete protein.
M36707 - Human calmodulin-like processed pseudogene, complete cds.
AK313934 - Homo sapiens cDNA, FLJ94574, Homo sapiens calmodulin-like 3 (CALML3), mRNA.
M58026 - Human NB-1 mRNA, complete cds.
BC031889 - Homo sapiens calmodulin-like 3, mRNA (cDNA clone MGC:30093 IMAGE:4777524), complete cds.
JD290728 - Sequence 271752 from Patent EP1572962.
KJ890815 - Synthetic construct Homo sapiens clone ccsbBroadEn_00209 CALML3 gene, encodes complete protein.
AB590316 - Synthetic construct DNA, clone: pFN21AE1412, Homo sapiens CALML3 gene for calmodulin-like 3, without stop codon, in Flexi system.
JD114291 - Sequence 95315 from Patent EP1572962.
JD279664 - Sequence 260688 from Patent EP1572962.
JD140228 - Sequence 121252 from Patent EP1572962.
JD259872 - Sequence 240896 from Patent EP1572962.
JD260120 - Sequence 241144 from Patent EP1572962.
JD171788 - Sequence 152812 from Patent EP1572962.
JD068105 - Sequence 49129 from Patent EP1572962.
JD538061 - Sequence 519085 from Patent EP1572962.
JD060329 - Sequence 41353 from Patent EP1572962.
JD398577 - Sequence 379601 from Patent EP1572962.
JD530391 - Sequence 511415 from Patent EP1572962.
JD160207 - Sequence 141231 from Patent EP1572962.
JD357747 - Sequence 338771 from Patent EP1572962.
JD249298 - Sequence 230322 from Patent EP1572962.
JD235541 - Sequence 216565 from Patent EP1572962.
JD222103 - Sequence 203127 from Patent EP1572962.
JD350673 - Sequence 331697 from Patent EP1572962.
JD079400 - Sequence 60424 from Patent EP1572962.
JD183571 - Sequence 164595 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04070 - Phosphatidylinositol signaling system
hsa04114 - Oocyte meiosis
hsa04270 - Vascular smooth muscle contraction
hsa04720 - Long-term potentiation
hsa04722 - Neurotrophin signaling pathway
hsa04740 - Olfactory transduction
hsa04744 - Phototransduction
hsa04910 - Insulin signaling pathway
hsa04912 - GnRH signaling pathway
hsa04916 - Melanogenesis
hsa05010 - Alzheimer's disease
hsa05214 - Glioma

-  Other Names for This Gene
  Alternate Gene Symbols: B2R9V6, CALL3_HUMAN, ENST00000315238.1, ENST00000315238.2, NM_005185, P27482, Q5SQI4, uc001iie.1, uc001iie.2, uc001iie.3
UCSC ID: ENST00000315238.3
RefSeq Accession: NM_005185
Protein: P27482 (aka CALL3_HUMAN or CALL_HUMAN)
CCDS: CCDS7069.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.