Human Gene UPF2 (ENST00000357604.10) from GENCODE V44
Description: Homo sapiens UPF2 regulator of nonsense mediated mRNA decay (UPF2), transcript variant 2, mRNA. (from RefSeq NM_015542) RefSeq Summary (NM_015542): This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000357604.10 Gencode Gene: ENSG00000151461.20 Transcript (Including UTRs) Position: hg38 chr10:11,920,022-12,042,809 Size: 122,788 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr10:11,921,298-12,035,423 Size: 114,126 Coding Exon Count: 21
ID:RENT2_HUMAN DESCRIPTION: RecName: Full=Regulator of nonsense transcripts 2; AltName: Full=Nonsense mRNA reducing factor 2; AltName: Full=Up-frameshift suppressor 2 homolog; Short=hUpf2; FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. SUBUNIT: Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1. INTERACTION: Q96Q15:SMG1; NbExp=6; IntAct=EBI-372073, EBI-1049832; Q92900:UPF1; NbExp=8; IntAct=EBI-372073, EBI-373471; Q9BZI7:UPF3B; NbExp=6; IntAct=EBI-372073, EBI-372780; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 3 MIF4G domains. SEQUENCE CAUTION: Sequence=BAA92646.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HAU5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.