Human Gene C10orf53 (ENST00000374112.7) from GENCODE V44
  Description: Homo sapiens chromosome 10 open reading frame 53 (C10orf53), transcript variant 1, mRNA. (from RefSeq NM_182554)
Gencode Transcript: ENST00000374112.7
Gencode Gene: ENSG00000178645.14
Transcript (Including UTRs)
   Position: hg38 chr10:49,679,686-49,710,261 Size: 30,576 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr10:49,679,698-49,708,617 Size: 28,920 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:49,679,686-49,710,261)mRNA (may differ from genome)Protein (157 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CJ053_HUMAN
DESCRIPTION: RecName: Full=UPF0728 protein C10orf53;
SIMILARITY: Belongs to the UPF0728 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.03 RPKM in Testis
Total median expression: 3.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -489.701644-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8N6V4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK296108 - Homo sapiens cDNA FLJ60598 complete cds, highly similar to Choline O-acetyltransferase (EC 2.3.1.6).
AK091773 - Homo sapiens cDNA FLJ34454 fis, clone HLUNG2002562.
AX747176 - Sequence 701 from Patent EP1308459.
BC028127 - Homo sapiens chromosome 10 open reading frame 53, mRNA (cDNA clone MGC:40171 IMAGE:5164374), complete cds.
KJ900538 - Synthetic construct Homo sapiens clone ccsbBroadEn_09932 C10orf53 gene, encodes complete protein.
JD276704 - Sequence 257728 from Patent EP1572962.
JD301506 - Sequence 282530 from Patent EP1572962.
JD052465 - Sequence 33489 from Patent EP1572962.
JD306858 - Sequence 287882 from Patent EP1572962.
JD120770 - Sequence 101794 from Patent EP1572962.
JD121557 - Sequence 102581 from Patent EP1572962.
JD364989 - Sequence 346013 from Patent EP1572962.
JD274320 - Sequence 255344 from Patent EP1572962.
JD151759 - Sequence 132783 from Patent EP1572962.
JD189248 - Sequence 170272 from Patent EP1572962.
JD111812 - Sequence 92836 from Patent EP1572962.
JD249356 - Sequence 230380 from Patent EP1572962.
JD266805 - Sequence 247829 from Patent EP1572962.
JD271554 - Sequence 252578 from Patent EP1572962.
JD483721 - Sequence 464745 from Patent EP1572962.
JD526720 - Sequence 507744 from Patent EP1572962.
JD142062 - Sequence 123086 from Patent EP1572962.
JD239179 - Sequence 220203 from Patent EP1572962.
JD333852 - Sequence 314876 from Patent EP1572962.
JD486748 - Sequence 467772 from Patent EP1572962.
JD162883 - Sequence 143907 from Patent EP1572962.
JD359297 - Sequence 340321 from Patent EP1572962.
JD563830 - Sequence 544854 from Patent EP1572962.
JD556197 - Sequence 537221 from Patent EP1572962.
JD265352 - Sequence 246376 from Patent EP1572962.
JD233310 - Sequence 214334 from Patent EP1572962.
JD268244 - Sequence 249268 from Patent EP1572962.
JD184811 - Sequence 165835 from Patent EP1572962.
JD475592 - Sequence 456616 from Patent EP1572962.
JD297675 - Sequence 278699 from Patent EP1572962.
JD279591 - Sequence 260615 from Patent EP1572962.
JD489528 - Sequence 470552 from Patent EP1572962.
JD274500 - Sequence 255524 from Patent EP1572962.
JD376264 - Sequence 357288 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NI81, A6NLE0, CJ053_HUMAN, ENST00000374112.1, ENST00000374112.2, ENST00000374112.3, ENST00000374112.4, ENST00000374112.5, ENST00000374112.6, NM_182554, Q8N6V4, uc001jid.1, uc001jid.2
UCSC ID: ENST00000374112.7
RefSeq Accession: NM_182554
Protein: Q8N6V4 (aka CJ053_HUMAN)
CCDS: CCDS31202.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.