Human Gene ZWINT (ENST00000395405.5) from GENCODE V44
Description: Homo sapiens ZW10 interacting kinetochore protein (ZWINT), transcript variant 2, mRNA. (from RefSeq NM_032997) RefSeq Summary (NM_032997): This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000395405.5 Gencode Gene: ENSG00000122952.17 Transcript (Including UTRs) Position: hg38 chr10:56,357,438-56,361,273 Size: 3,836 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr10:56,358,418-56,361,236 Size: 2,819 Coding Exon Count: 8
ID:ZWINT_HUMAN DESCRIPTION: RecName: Full=ZW10 interactor; AltName: Full=ZW10-interacting protein 1; Short=Zwint-1; FUNCTION: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. SUBUNIT: Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1. INTERACTION: O14777:NDC80; NbExp=11; IntAct=EBI-1001132, EBI-715849; O43264:ZW10; NbExp=6; IntAct=EBI-1001132, EBI-1001217; SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on O95229
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK093808 - Homo sapiens cDNA FLJ36489 fis, clone THYMU2018126, highly similar to ZW10 interactor. LF384646 - JP 2014500723-A/192149: Polycomb-Associated Non-Coding RNAs. MA620223 - JP 2018138019-A/192149: Polycomb-Associated Non-Coding RNAs. AF067656 - Homo sapiens ZW10 interactor Zwint mRNA, complete cds. AK225509 - Homo sapiens mRNA for ZW10 interactor variant, clone: KAT01661. BC020979 - Homo sapiens ZW10 interactor, mRNA (cDNA clone MGC:9699 IMAGE:3848873), complete cds. BC110399 - Homo sapiens ZW10 interactor, mRNA (cDNA clone MGC:117174 IMAGE:5554405), complete cds. AK298148 - Homo sapiens cDNA FLJ55119 complete cds, highly similar to Homo sapiens ZW10 interactor (ZWINT), transcript variant 3, mRNA. AK293416 - Homo sapiens cDNA FLJ60420 complete cds, highly similar to ZW10 interactor. JF432678 - Synthetic construct Homo sapiens clone IMAGE:100073916 ZW10 interactor (ZWINT) gene, encodes complete protein. KJ898363 - Synthetic construct Homo sapiens clone ccsbBroadEn_07757 ZWINT gene, encodes complete protein. BC016357 - Homo sapiens ZW10 interactor, mRNA (cDNA clone IMAGE:4094672), partial cds. BC000411 - Homo sapiens, clone IMAGE:2961008, mRNA, partial cds. JD496267 - Sequence 477291 from Patent EP1572962. JD553938 - Sequence 534962 from Patent EP1572962. JD247657 - Sequence 228681 from Patent EP1572962. JD563538 - Sequence 544562 from Patent EP1572962. JD531105 - Sequence 512129 from Patent EP1572962. JD223684 - Sequence 204708 from Patent EP1572962. JD188942 - Sequence 169966 from Patent EP1572962. JD334250 - Sequence 315274 from Patent EP1572962. JD524930 - Sequence 505954 from Patent EP1572962. JD503654 - Sequence 484678 from Patent EP1572962. JD387041 - Sequence 368065 from Patent EP1572962. JD391160 - Sequence 372184 from Patent EP1572962. JD196773 - Sequence 177797 from Patent EP1572962. JD132852 - Sequence 113876 from Patent EP1572962. LF322791 - JP 2014500723-A/130294: Polycomb-Associated Non-Coding RNAs. MA558368 - JP 2018138019-A/130294: Polycomb-Associated Non-Coding RNAs. JD439354 - Sequence 420378 from Patent EP1572962. JD187908 - Sequence 168932 from Patent EP1572962. JD471252 - Sequence 452276 from Patent EP1572962. JD555842 - Sequence 536866 from Patent EP1572962. JD400579 - Sequence 381603 from Patent EP1572962. LF322790 - JP 2014500723-A/130293: Polycomb-Associated Non-Coding RNAs. MA558367 - JP 2018138019-A/130293: Polycomb-Associated Non-Coding RNAs. LF322789 - JP 2014500723-A/130292: Polycomb-Associated Non-Coding RNAs. MA558366 - JP 2018138019-A/130292: Polycomb-Associated Non-Coding RNAs. LF359976 - JP 2014500723-A/167479: Polycomb-Associated Non-Coding RNAs. MA595553 - JP 2018138019-A/167479: Polycomb-Associated Non-Coding RNAs. LF322788 - JP 2014500723-A/130291: Polycomb-Associated Non-Coding RNAs. MA558365 - JP 2018138019-A/130291: Polycomb-Associated Non-Coding RNAs. LF359975 - JP 2014500723-A/167478: Polycomb-Associated Non-Coding RNAs. MA595552 - JP 2018138019-A/167478: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95229 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
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