Human Gene HNRNPH3 (ENST00000265866.12) from GENCODE V44
Description: Homo sapiens heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), transcript variant 2H9, mRNA. (from RefSeq NM_012207) RefSeq Summary (NM_012207): This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000265866.12 Gencode Gene: ENSG00000096746.18 Transcript (Including UTRs) Position: hg38 chr10:68,332,064-68,343,193 Size: 11,130 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr10:68,337,222-68,342,054 Size: 4,833 Coding Exon Count: 9
ID:HNRH3_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein H3; Short=hnRNP H3; AltName: Full=Heterogeneous nuclear ribonucleoprotein 2H9; Short=hnRNP 2H9; FUNCTION: Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31942
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
