Human Gene PLA2G12B (ENST00000373032.4) from GENCODE V44
Description: Homo sapiens phospholipase A2 group XIIB (PLA2G12B), transcript variant 1, mRNA. (from RefSeq NM_032562) RefSeq Summary (NM_032562): The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000373032.4 Gencode Gene: ENSG00000138308.6 Transcript (Including UTRs) Position: hg38 chr10:72,934,762-72,954,806 Size: 20,045 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr10:72,935,617-72,954,685 Size: 19,069 Coding Exon Count: 4
ID:PG12B_HUMAN DESCRIPTION: RecName: Full=Group XIIB secretory phospholipase A2-like protein; AltName: Full=Group XIII secretory phospholipase A2-like protein; Short=GXIII sPLA2-like; AltName: Full=sPLA2-GXIIB; Short=GXIIB; Flags: Precursor; FUNCTION: Not known; does not seem to have catalytic activity. COFACTOR: Binds 1 calcium ion per subunit (By similarity). SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Strong expression in liver, small intestine and kidney. SIMILARITY: Belongs to the phospholipase A2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06951 - Group XII secretory phospholipase A2 precursor (PLA2G12)
ModBase Predicted Comparative 3D Structure on Q9BX93
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
