Human Gene ENTPD1 (ENST00000453258.6) from GENCODE V44
Description: Homo sapiens ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), transcript variant 2, mRNA. (from RefSeq NM_001098175) RefSeq Summary (NM_001098175): The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. Gencode Transcript: ENST00000453258.6 Gencode Gene: ENSG00000138185.20 Transcript (Including UTRs) Position: hg38 chr10:95,711,779-95,869,695 Size: 157,917 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr10:95,711,957-95,866,383 Size: 154,427 Coding Exon Count: 10
ID:ENTP1_HUMAN DESCRIPTION: RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 1; Short=NTPDase 1; EC=3.6.1.5; AltName: Full=Ecto-ATP diphosphohydrolase 1; Short=Ecto-ATPDase 1; Short=Ecto-ATPase 1; AltName: Full=Ecto-apyrase; AltName: Full=Lymphoid cell activation antigen; AltName: CD_antigen=CD39; FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. CATALYTIC ACTIVITY: ATP + 2 H(2)O = AMP + 2 phosphate. COFACTOR: Calcium. COFACTOR: Magnesium. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.0-7.5 with ATP as substrate, and 7.5-8.0 with ADP as substrate; SUBUNIT: Homodimer; disulfide-linked (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only. PTM: The N-terminus is blocked. PTM: Palmitoylated in the N-terminal part. SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01150 - GDA1/CD39 (nucleoside phosphatase) family
ModBase Predicted Comparative 3D Structure on P49961
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
