Human Gene FGF8 (ENST00000320185.7) from GENCODE V44
  Description: Homo sapiens fibroblast growth factor 8 (FGF8), transcript variant F, mRNA. (from RefSeq NM_033163)
RefSeq Summary (NM_033163): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000320185.7
Gencode Gene: ENSG00000107831.14
Transcript (Including UTRs)
   Position: hg38 chr10:101,770,109-101,776,114 Size: 6,006 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr10:101,770,329-101,775,900 Size: 5,572 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:101,770,109-101,776,114)mRNA (may differ from genome)Protein (244 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Fibroblast growth factor 8; Short=FGF-8; AltName: Full=Androgen-induced growth factor; Short=AIGF; AltName: Full=Heparin-binding growth factor 8; Short=HBGF-8; Flags: Precursor;
FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
DEVELOPMENTAL STAGE: In adults expression is restricted to the gonads.
DISEASE: Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone- synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
DISEASE: Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
SIMILARITY: Belongs to the heparin-binding growth factors family.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: FGF8
Diseases sorted by gene-association score: hypogonadotropic hypogonadism 6 with or without anosmia* (1231), fgf8-related isolated gonadotropin-releasing hormone deficiency* (500), kallmann syndrome 6* (400), kallmann syndrome* (149), semilobar holoprosencephaly* (111), septopreoptic holoprosencephaly* (106), midline interhemispheric variant of holoprosencephaly* (106), microform holoprosencephaly* (101), lobar holoprosencephaly* (94), alobar holoprosencephaly* (94), normosmic congenital hypogonadotropic hypogonadism* (88), hartsfield syndrome (13), deafness, autosomal recessive 51 (11), hypogonadotropic hypogonadism (11), craniosynostosis (10), hypogonadism (10), pfeiffer syndrome (8), holoprosencephaly (8), hypospadias (8), prostatic hypertrophy (7), thanatophoric dysplasia, type i (6), split hand-split foot malformation (6), axenfeld-rieger syndrome, type 1 (5), split foot (5), charge syndrome (5), ladd syndrome (5), thrombocytopenia-absent radius syndrome (4), split hand-foot malformation 2 (4), split-hand/foot malformation 3 (4), spinocerebellar ataxia, autosomal recessive 1 (4), agnathia-otocephaly complex (4), muenke syndrome (4), breast cancer (2), cryptorchidism (2), parkinson disease, late-onset (2), prostate cancer (1), physical disorder (1), conotruncal heart malformations (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.54 RPKM in Testis
Total median expression: 3.53 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.90214-0.593 Picture PostScript Text
3' UTR -70.50220-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2FDB - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P55075
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0042056 chemoattractant activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001839 neural plate morphogenesis
GO:0001947 heart looping
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007275 multicellular organism development
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007507 heart development
GO:0008045 motor neuron axon guidance
GO:0008078 mesodermal cell migration
GO:0008284 positive regulation of cell proliferation
GO:0008406 gonad development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0009792 embryo development ending in birth or egg hatching
GO:0010469 regulation of receptor activity
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021846 cell proliferation in forebrain
GO:0021884 forebrain neuron development
GO:0021954 central nervous system neuron development
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030509 BMP signaling pathway
GO:0030539 male genitalia development
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030917 midbrain-hindbrain boundary development
GO:0033563 dorsal/ventral axon guidance
GO:0035050 embryonic heart tube development
GO:0035108 limb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035909 aorta morphogenesis
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045840 positive regulation of mitotic nuclear division
GO:0046622 positive regulation of organ growth
GO:0046854 phosphatidylinositol phosphorylation
GO:0048699 generation of neurons
GO:0048853 forebrain morphogenesis
GO:0050918 positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060037 pharyngeal system development
GO:0060070 canonical Wnt signaling pathway
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060348 bone development
GO:0060425 lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071542 dopaminergic neuron differentiation
GO:0090134 cell migration involved in mesendoderm migration

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0009897 external side of plasma membrane

-  Descriptions from all associated GenBank mRNAs
  LF211351 - JP 2014500723-A/18854: Polycomb-Associated Non-Coding RNAs.
MA446928 - JP 2018138019-A/18854: Polycomb-Associated Non-Coding RNAs.
BC069106 - Homo sapiens fibroblast growth factor 8 (androgen-induced), mRNA (cDNA clone MGC:95383 IMAGE:7216922), complete cds.
U46214 - Human fibroblast growth factor 8, 3' untranslated region.
BC128236 - Homo sapiens fibroblast growth factor 8 (androgen-induced), mRNA (cDNA clone MGC:149376 IMAGE:40114672), complete cds.
BC128235 - Homo sapiens fibroblast growth factor 8 (androgen-induced), mRNA (cDNA clone MGC:149375 IMAGE:40114671), complete cds.
JD349525 - Sequence 330549 from Patent EP1572962.
AB014615 - Homo sapiens mRNA for FGF8f, complete cds.
U36223 - Human fibroblast growth factor 8 (FGF-8) mRNA, complete cds.
U56978 - Human fibroblast growth factor 8 (FGF-8) mRNA, complete cds.
U46211 - Human fibroblast growth factor 8 isoform a (FGF8) mRNA, complete cds.
U46212 - Human fibroblast growth factor 8 isoform b (FGF8) mRNA, complete cds.
U46213 - Human fibroblast growth factor 8 isoform e (FGF8) mRNA, complete cds.
KJ896814 - Synthetic construct Homo sapiens clone ccsbBroadEn_06208 FGF8 gene, encodes complete protein.
KR711971 - Synthetic construct Homo sapiens clone CCSBHm_00033231 FGF8 (FGF8) mRNA, encodes complete protein.
KR711972 - Synthetic construct Homo sapiens clone CCSBHm_00033232 FGF8 (FGF8) mRNA, encodes complete protein.
LF212795 - JP 2014500723-A/20298: Polycomb-Associated Non-Coding RNAs.
MA448372 - JP 2018138019-A/20298: Polycomb-Associated Non-Coding RNAs.
LF213451 - JP 2014500723-A/20954: Polycomb-Associated Non-Coding RNAs.
MA449028 - JP 2018138019-A/20954: Polycomb-Associated Non-Coding RNAs.
JD405941 - Sequence 386965 from Patent EP1572962.
JD142471 - Sequence 123495 from Patent EP1572962.
JD458593 - Sequence 439617 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P55075 (Reactome details) participates in the following event(s):

R-HSA-190256 FGFR1c binds to FGF
R-HSA-2023451 FGFR1c P252X mutants bind ligand with enhanced affinity
R-HSA-190261 FGFR3c binds to FGF
R-HSA-2012074 FGFR3c P250R mutant binds to ligand with enhanced affinity
R-HSA-190265 FGFR4 binds to FGF
R-HSA-190263 FGFR3b binds to FGF
R-HSA-5654511 FGFRL1 dimer binds FGFs
R-HSA-190429 Autocatalytic phosphorylation of FGFR1c
R-HSA-2023455 Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
R-HSA-190388 Autocatalytic phosphorylation of FGFR3c
R-HSA-2012073 Autocatalytic phosphorylation of FGFR3c P250R mutant
R-HSA-2033472 FGFR2c mutants bind an expanded range of ligands
R-HSA-190326 Autocatalytic phosphorylation of FGFR4
R-HSA-190385 Autocatalytic phosphorylation of FGFR3b
R-HSA-5654167 Activated FGFR1 binds PLCG1
R-HSA-5654569 Activated FGFR1 binds FRS2
R-HSA-5654571 Activated FGFR1 binds FRS3
R-HSA-5654573 Activated FGFR1 binds SHC1
R-HSA-5656064 Activated FGFR1 binds FLRT1,2,3
R-HSA-5654165 p-4Y-PLCG1 dissociates from activated FGFR1
R-HSA-5655269 Activated FGFR1 mutants bind FRS2
R-HSA-5654224 Activated FGFR3 binds PLCG1
R-HSA-5654409 Activated FGFR3 binds FRS2
R-HSA-5654623 Activated FGFR3 binds FRS3
R-HSA-5654625 Activated FGFR3 binds SHC1
R-HSA-5654148 p-4Y-PLCG1 dissociates from activated FGFR3
R-HSA-2077420 FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655244 Activated FGFR3 mutants bind PLCG1
R-HSA-5655262 Activated FGFR3 mutants bind FRS2
R-HSA-5655247 p-4Y-PLCG1 dissociates from activated FGFR3 mutants
R-HSA-190413 Autocatalytic phosphorylation of FGFR2c
R-HSA-2033486 Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
R-HSA-5654163 Activated FGFR4 binds PLCG1
R-HSA-5654422 Activated FGFR4 binds FRS2
R-HSA-5654425 Activated FGFR4 binds SHC1
R-HSA-5654651 Activated FGFR4 binds FRS3
R-HSA-5654169 p-4Y-PLCG1 dissociates from activated FGFR4
R-HSA-5654149 Activated FGFR1 phosphorylates PLCG1
R-HSA-5654560 Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
R-HSA-5654575 Activated FGFR1 phosphorylates FRS2
R-HSA-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654578 Activated FGFR1 phosphorylates FRS3
R-HSA-5654582 Activated FGFR1 phosphorylates SHC1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5655240 Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655266 Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655278 Activated FGFR1 mutants phosphorylate FRS2
R-HSA-1839094 Activated FGFR1 mutants and fusions bind PLCG1
R-HSA-1839100 p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
R-HSA-5654222 Activated FGFR3 phosphorylates PLCG1
R-HSA-5654408 Activated FGFR3 phosphorylates FRS2
R-HSA-5654565 Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
R-HSA-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654628 Activated FGFR3 phosphorylates FRS3
R-HSA-5654634 Activated FGFR3 phosphorylates SHC1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5655295 Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655315 Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655270 Activated FGFR3 mutants phosphorylate FRS2
R-HSA-5655243 Activated FGFR3 mutants phosphorylate PLCG1
R-HSA-5654159 Activated FGFR2 binds PLCG1
R-HSA-5654399 Activated FGFR2 binds FRS2
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654603 Activated FGFR2 binds FRS3
R-HSA-5654157 p-4Y-PLCG1 dissociates from activated FGFR2
R-HSA-2077424 Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655339 Activated FGFR2 mutants bind FRS2
R-HSA-5655343 Activated FGFR2 mutants bind PLCG1
R-HSA-5654748 p-4Y-PLCG1 dissociates from activated FGFR2 mutants
R-HSA-5654151 Activated FGFR4 phosphorylates PLCG1
R-HSA-5654418 Activated FGFR4 phosphorylates FRS2
R-HSA-5654566 Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
R-HSA-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654653 Activated FGFR4 phosphorylates FRS3
R-HSA-5654428 Activated FGFR4 phosphorylates SHC1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654673 p-CBL:GRB2 binds p-FRS2:activated FGFR1
R-HSA-5654584 Activated FGFR1:p-FRS bind to PPTN11
R-HSA-5654586 Activated FGFR1:p-FRS binds GRB2:SOS1
R-HSA-5655263 Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-1839098 Activated FGFR1 mutants and fusions phosphorylate PLCG1
R-HSA-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654730 p-CBL:GRB2 binds p-FRS2:activated FGFR3
R-HSA-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654416 Activated FGFR3:pFRS binds GRB2:SOS1
R-HSA-5654633 Activated FGFR3:p-FRS bind to PPTN11
R-HSA-5655285 Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654147 Activated FGFR2 phosphorylates PLCG1
R-HSA-5654397 Activated FGFR2 phosphorylates FRS2
R-HSA-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654605 Activated FGFR2 phosphorylates FRS3
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5655301 Activated FGFR2 mutants phosphorylate PLCG1
R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655268 Activated FGFR2 mutants phosphorylate FRS2
R-HSA-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654734 p-CBL:GRB2 binds p-FRS2:activated FGFR4
R-HSA-5654658 Activated FGFR4:p-FRS bind to PPTN11
R-HSA-5654664 Activated FGFR4:p-FRS binds GRB2:SOS1
R-HSA-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654672 CBL ubiquitinates FRS2 and FGFR1
R-HSA-5654587 Activated FGFR1:p-FRS phosphorylates PPTN11
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654679 CBL ubiquitinates FRS2 and FGFR3
R-HSA-5654631 Activated FGFR3 phosphorylates PPTN11
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654608 Activated FGFR2:p-FRS bind to PPTN11
R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-HSA-5654684 CBL ubiquitinates FRS2 and FGFR4
R-HSA-5654655 Activated FGFR4 phosphorylates PPTN11
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-5655290 Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2
R-HSA-5654607 Activated FGFR2 phosphorylates PPTN11
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190371 FGFR3b ligand binding and activation
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-190242 FGFR1 ligand binding and activation
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-190239 FGFR3 ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654743 Signaling by FGFR4
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-5654741 Signaling by FGFR3
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-190236 Signaling by FGFR
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-5663202 Diseases of signal transduction
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-109704 PI3K Cascade
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5683057 MAPK family signaling cascades
R-HSA-112399 IRS-mediated signalling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

-  Other Names for This Gene
  Alternate Gene Symbols: A1A514, AIGF, ENST00000320185.1, ENST00000320185.2, ENST00000320185.3, ENST00000320185.4, ENST00000320185.5, ENST00000320185.6, FGF8_HUMAN, NM_033163, P55075, Q14915, Q15766, uc001ktq.1, uc001ktq.2, uc001ktq.3, uc001ktq.4
UCSC ID: ENST00000320185.7
RefSeq Accession: NM_033163
Protein: P55075 (aka FGF8_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene FGF8:
kms (Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency)
hpe-overview (Holoprosencephaly Overview)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.