Human Gene WBP1L (ENST00000448841.7) from GENCODE V44
  Description: Homo sapiens WW domain binding protein 1 like (WBP1L), transcript variant 1, mRNA. (from RefSeq NM_001083913)
Gencode Transcript: ENST00000448841.7
Gencode Gene: ENSG00000166272.18
Transcript (Including UTRs)
   Position: hg38 chr10:102,743,948-102,816,262 Size: 72,315 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr10:102,744,054-102,813,331 Size: 69,278 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:102,743,948-102,816,262)mRNA (may differ from genome)Protein (363 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=WW domain binding protein 1-like; AltName: Full=Outcome predictor in acute leukemia 1;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=BAA91122.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.11 RPKM in Thyroid
Total median expression: 891.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.90106-0.065 Picture PostScript Text
3' UTR -1031.002931-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021684 - Uncharacterised_WW-bd

Pfam Domains:
PF11669 - WW domain-binding protein 1

ModBase Predicted Comparative 3D Structure on Q9NX94
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK300871 - Homo sapiens cDNA FLJ58693 complete cds.
AK316452 - Homo sapiens cDNA, FLJ79351 complete cds.
AK308843 - Homo sapiens cDNA, FLJ98884.
AY656172 - Homo sapiens outcome predictor in acute leukemia 1 (OPAL1) mRNA, exon 1a and partial cds.
AY656171 - Homo sapiens outcome predictor in acute leukemia 1 (OPAL1) mRNA, complete cds.
AK056285 - Homo sapiens cDNA FLJ31723 fis, clone NT2RI2006682, weakly similar to Human WW domain binding protein-1 mRNA.
BC113857 - Homo sapiens chromosome 10 open reading frame 26, mRNA (cDNA clone MGC:125648 IMAGE:40027916), complete cds.
BC114465 - Homo sapiens chromosome 10 open reading frame 26, mRNA (cDNA clone MGC:125647 IMAGE:40027914), complete cds.
JD254881 - Sequence 235905 from Patent EP1572962.
AK000374 - Homo sapiens cDNA FLJ20367 fis, clone HEP18101.
JD317283 - Sequence 298307 from Patent EP1572962.
JD077181 - Sequence 58205 from Patent EP1572962.
JD296140 - Sequence 277164 from Patent EP1572962.
JD370329 - Sequence 351353 from Patent EP1572962.
JD115355 - Sequence 96379 from Patent EP1572962.
JD363978 - Sequence 345002 from Patent EP1572962.
DQ585838 - Homo sapiens piRNA piR-52950, complete sequence.
JD165753 - Sequence 146777 from Patent EP1572962.
JD297991 - Sequence 279015 from Patent EP1572962.
JD132747 - Sequence 113771 from Patent EP1572962.
JD282673 - Sequence 263697 from Patent EP1572962.
JD324869 - Sequence 305893 from Patent EP1572962.
JD562542 - Sequence 543566 from Patent EP1572962.
JD468993 - Sequence 450017 from Patent EP1572962.
JD546194 - Sequence 527218 from Patent EP1572962.
JD043452 - Sequence 24476 from Patent EP1572962.
JD179017 - Sequence 160041 from Patent EP1572962.
JD136845 - Sequence 117869 from Patent EP1572962.
JD160660 - Sequence 141684 from Patent EP1572962.
JD484804 - Sequence 465828 from Patent EP1572962.
JD193472 - Sequence 174496 from Patent EP1572962.
JD554802 - Sequence 535826 from Patent EP1572962.
JD046093 - Sequence 27117 from Patent EP1572962.
JD536396 - Sequence 517420 from Patent EP1572962.
DQ580641 - Homo sapiens piRNA piR-48753, complete sequence.
JD187585 - Sequence 168609 from Patent EP1572962.
JD465321 - Sequence 446345 from Patent EP1572962.
JD522689 - Sequence 503713 from Patent EP1572962.
JD067469 - Sequence 48493 from Patent EP1572962.
AK000161 - Homo sapiens cDNA FLJ20154 fis, clone COL08740.
JD507332 - Sequence 488356 from Patent EP1572962.
JD469061 - Sequence 450085 from Patent EP1572962.
JD428465 - Sequence 409489 from Patent EP1572962.
JD253212 - Sequence 234236 from Patent EP1572962.
BC010506 - Homo sapiens chromosome 10 open reading frame 26, mRNA (cDNA clone IMAGE:4148754).
AF070644 - Homo sapiens clone 24742 mRNA sequence.
BC063659 - Homo sapiens cDNA clone IMAGE:5001157, partial cds.
BC073886 - Homo sapiens cDNA clone IMAGE:4997178, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KPF4, B7Z6S7, C10orf26, D3DR90, ENST00000448841.1, ENST00000448841.2, ENST00000448841.3, ENST00000448841.4, ENST00000448841.5, ENST00000448841.6, NM_001083913, OPA1L, Q1EG70, Q2HIY7, Q5F2G6, Q9NX94, uc001kwf.1, uc001kwf.2, uc001kwf.3, uc001kwf.4, uc001kwf.5, uc001kwf.6, uc001kwf.7, WBP1L_HUMAN
UCSC ID: ENST00000448841.7
RefSeq Accession: NM_001083913
Protein: Q9NX94 (aka WBP1L_HUMAN)
CCDS: CCDS44473.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.