Human Gene BAG3 (ENST00000369085.8) from GENCODE V44
Description: Homo sapiens BAG cochaperone 3 (BAG3), mRNA. (from RefSeq NM_004281) RefSeq Summary (NM_004281): BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000369085.8 Gencode Gene: ENSG00000151929.10 Transcript (Including UTRs) Position: hg38 chr10:119,651,380-119,677,819 Size: 26,440 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr10:119,651,676-119,677,282 Size: 25,607 Coding Exon Count: 4
ID:BAG3_HUMAN DESCRIPTION: RecName: Full=BAG family molecular chaperone regulator 3; Short=BAG-3; AltName: Full=Bcl-2-associated athanogene 3; AltName: Full=Bcl-2-binding protein Bis; AltName: Full=Docking protein CAIR-1; FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. SUBUNIT: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6. DISEASE: Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. DISEASE: Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH) [MIM:613881]. CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. SIMILARITY: Contains 1 BAG domain. SIMILARITY: Contains 2 WW domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BAG3ID43160ch10q26.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95817
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0006915 apoptotic process GO:0007420 brain development GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0010664 negative regulation of striated muscle cell apoptotic process GO:0021510 spinal cord development GO:0034605 cellular response to heat GO:0042307 positive regulation of protein import into nucleus GO:0043066 negative regulation of apoptotic process GO:0046827 positive regulation of protein export from nucleus GO:0050790 regulation of catalytic activity GO:0050821 protein stabilization GO:0071260 cellular response to mechanical stimulus GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress GO:1900034 regulation of cellular response to heat GO:1903215 negative regulation of protein targeting to mitochondrion
LF207932 - JP 2014500723-A/15435: Polycomb-Associated Non-Coding RNAs. MA443509 - JP 2018138019-A/15435: Polycomb-Associated Non-Coding RNAs. AF071218 - Homo sapiens docking protein CAIR-1 mRNA, complete cds. AF095193 - Homo sapiens BAG-family molecular chaperone regulator-3 mRNA, complete cds. JB982103 - Sequence 18 from Patent WO2013189775. AK222800 - Homo sapiens mRNA for BCL2-associated athanogene 3 variant, clone: HEP03825. BC006418 - Homo sapiens BCL2-associated athanogene 3, mRNA (cDNA clone MGC:12641 IMAGE:3635446), complete cds. AF127139 - Homo sapiens Bcl-2-binding protein BIS (BIS) mRNA, complete cds. AK313026 - Homo sapiens cDNA, FLJ93496. AL137582 - Homo sapiens mRNA; cDNA DKFZp434E0610 (from clone DKFZp434E0610); partial cds. BC107786 - Homo sapiens BCL2-associated athanogene 3, mRNA (cDNA clone MGC:104307 IMAGE:6655146), complete cds. AK291333 - Homo sapiens cDNA FLJ75690 complete cds, highly similar to Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA. BC014656 - Homo sapiens BCL2-associated athanogene 3, mRNA (cDNA clone MGC:20407 IMAGE:4636684), complete cds. DQ896772 - Synthetic construct Homo sapiens clone IMAGE:100011232; FLH199403.01L; RZPDo839E0581D BCL2-associated athanogene 3 (BAG3) gene, encodes complete protein. DQ893416 - Synthetic construct clone IMAGE:100006046; FLH199497.01X; RZPDo839E0582D BCL2-associated athanogene 3 (BAG3) gene, encodes complete protein. CU675397 - Synthetic construct Homo sapiens gateway clone IMAGE:100019899 5' read BAG3 mRNA. KJ906000 - Synthetic construct Homo sapiens clone ccsbBroadEn_15670 BAG3 gene, encodes complete protein. AB385565 - Synthetic construct DNA, clone: pF1KB9402, Homo sapiens BAG3 gene for BAG family molecular chaperone regulator 3, complete cds, without stop codon, in Flexi system. JD464557 - Sequence 445581 from Patent EP1572962. JD125857 - Sequence 106881 from Patent EP1572962. JD042033 - Sequence 23057 from Patent EP1572962. JD321895 - Sequence 302919 from Patent EP1572962. JD403677 - Sequence 384701 from Patent EP1572962. JD460805 - Sequence 441829 from Patent EP1572962. JD365760 - Sequence 346784 from Patent EP1572962. JD462632 - Sequence 443656 from Patent EP1572962. JD331165 - Sequence 312189 from Patent EP1572962. JD141582 - Sequence 122606 from Patent EP1572962. JD095094 - Sequence 76118 from Patent EP1572962. JD211261 - Sequence 192285 from Patent EP1572962. LF370098 - JP 2014500723-A/177601: Polycomb-Associated Non-Coding RNAs. MA605675 - JP 2018138019-A/177601: Polycomb-Associated Non-Coding RNAs. LF370099 - JP 2014500723-A/177602: Polycomb-Associated Non-Coding RNAs. MA605676 - JP 2018138019-A/177602: Polycomb-Associated Non-Coding RNAs. MP083704 - Sequence 1 from Patent EP3337518. JD260962 - Sequence 241986 from Patent EP1572962. JD166158 - Sequence 147182 from Patent EP1572962. LF370100 - JP 2014500723-A/177603: Polycomb-Associated Non-Coding RNAs. MA605677 - JP 2018138019-A/177603: Polycomb-Associated Non-Coding RNAs. JD562975 - Sequence 543999 from Patent EP1572962. LF370101 - JP 2014500723-A/177604: Polycomb-Associated Non-Coding RNAs. MA605678 - JP 2018138019-A/177604: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95817 (Reactome details) participates in the following event(s):
R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli