Human Gene NPS (ENST00000398023.3) from GENCODE V44
  Description: Homo sapiens neuropeptide S (NPS), mRNA. (from RefSeq NM_001030013)
Gencode Transcript: ENST00000398023.3
Gencode Gene: ENSG00000214285.3
Transcript (Including UTRs)
   Position: hg38 chr10:127,549,309-127,553,540 Size: 4,232 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr10:127,549,369-127,552,639 Size: 3,271 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:127,549,309-127,553,540)mRNA (may differ from genome)Protein (89 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPS_HUMAN
DESCRIPTION: RecName: Full=Neuropeptide S; Flags: Precursor;
FUNCTION: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity).
SUBCELLULAR LOCATION: Secreted.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NPS
Diseases sorted by gene-association score: spinocerebellar ataxia 23 (11), adrenal gland pheochromocytoma (10), retinitis pigmentosa 68 (7), reflex sympathetic dystrophy (7), spongiotic dermatitis (6), diverticulitis of colon (6), alcohol-induced mental disorder (6), epicondylitis (6), dental pulp disease (6), dissociative amnesia (6), autonomic nervous system disease (5), alcoholic psychosis (5), sleep disorder (5), cloacogenic carcinoma (5), sebaceous gland disease (4), amphetamine abuse (4), neurodermatitis (4), nasal cavity disease (4), perry syndrome (4), indeterminate leprosy (4), holoprosencephaly 3 (3), migraine with or without aura 1 (2), disease of mental health (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.6060-0.127 Picture PostScript Text
3' UTR -210.20901-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on P0C0P6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0008542 visual learning
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0045760 positive regulation of action potential
GO:0051968 positive regulation of synaptic transmission, glutamatergic

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  BC148465 - Synthetic construct Homo sapiens clone IMAGE:100015380, MGC:183012 neuropeptide S (NPS) mRNA, encodes complete protein.
BC156665 - Synthetic construct Homo sapiens clone IMAGE:100062177, MGC:190193 neuropeptide S (NPS) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P0C0P6 (Reactome details) participates in the following event(s):

R-HSA-444620 Neuropeptide S receptor binds neuropeptide S
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000398023.1, ENST00000398023.2, NM_001030013, NPS_HUMAN, P0C0P6, uc001ljx.1, uc001ljx.2, uc001ljx.3
UCSC ID: ENST00000398023.3
RefSeq Accession: NM_001030013
Protein: P0C0P6 (aka NPS_HUMAN)
CCDS: CCDS41577.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.