Human Gene UTF1 (ENST00000304477.3) from GENCODE V44
  Description: Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA. (from RefSeq NM_003577)
RefSeq Summary (NM_003577): The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015].
Gencode Transcript: ENST00000304477.3
Gencode Gene: ENSG00000171794.4
Transcript (Including UTRs)
   Position: hg38 chr10:133,230,217-133,231,558 Size: 1,342 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr10:133,230,289-133,231,442 Size: 1,154 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:133,230,217-133,231,558)mRNA (may differ from genome)Protein (341 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UTF1_HUMAN
DESCRIPTION: RecName: Full=Undifferentiated embryonic cell transcription factor 1;
FUNCTION: Acts as a transcriptional coactivator of ATF2.
SUBUNIT: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
SUBCELLULAR LOCATION: Nucleus (Probable).
DOMAIN: The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
PTM: Phosphorylated.
SEQUENCE CAUTION: Sequence=AAT38949.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: UTF1
Diseases sorted by gene-association score: opportunistic bacterial infectious disease (9), nocardiosis (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.07 RPKM in Testis
Total median expression: 7.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.0072-0.403 Picture PostScript Text
3' UTR -26.10116-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026651 - UTF1

ModBase Predicted Comparative 3D Structure on Q5T230
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0071837 HMG box domain binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008584 male gonad development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF207950 - JP 2014500723-A/15453: Polycomb-Associated Non-Coding RNAs.
MA443527 - JP 2018138019-A/15453: Polycomb-Associated Non-Coding RNAs.
AB011076 - Homo sapiens UTF1 mRNA for undifferentiated embryonic cell transcription factor 1, complete cds.
AY606112 - Homo sapiens ES protein mRNA, partial cds.
BC166624 - Synthetic construct Homo sapiens clone IMAGE:100066350, MGC:195487 undifferentiated embryonic cell transcription factor 1 (UTF1) mRNA, encodes complete protein.
LF370465 - JP 2014500723-A/177968: Polycomb-Associated Non-Coding RNAs.
MA606042 - JP 2018138019-A/177968: Polycomb-Associated Non-Coding RNAs.
LF370467 - JP 2014500723-A/177970: Polycomb-Associated Non-Coding RNAs.
MA606044 - JP 2018138019-A/177970: Polycomb-Associated Non-Coding RNAs.
JD559054 - Sequence 540078 from Patent EP1572962.
JD127959 - Sequence 108983 from Patent EP1572962.
JD210850 - Sequence 191874 from Patent EP1572962.
JD417027 - Sequence 398051 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000304477.1, ENST00000304477.2, NM_003577, O75833, Q5T230, Q6J1H3, uc001lmc.1, uc001lmc.2, uc001lmc.3, uc001lmc.4, UTF1_HUMAN
UCSC ID: ENST00000304477.3
RefSeq Accession: NM_003577
Protein: Q5T230 (aka UTF1_HUMAN)
CCDS: CCDS31318.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.