Human Gene UTF1 (ENST00000304477.3) from GENCODE V44
Description: Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA. (from RefSeq NM_003577) RefSeq Summary (NM_003577): The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]. Gencode Transcript: ENST00000304477.3 Gencode Gene: ENSG00000171794.4 Transcript (Including UTRs) Position: hg38 chr10:133,230,217-133,231,558 Size: 1,342 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr10:133,230,289-133,231,442 Size: 1,154 Coding Exon Count: 2
ID:UTF1_HUMAN DESCRIPTION: RecName: Full=Undifferentiated embryonic cell transcription factor 1; FUNCTION: Acts as a transcriptional coactivator of ATF2. SUBUNIT: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP. SUBCELLULAR LOCATION: Nucleus (Probable). DOMAIN: The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity). PTM: Phosphorylated. SEQUENCE CAUTION: Sequence=AAT38949.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T230
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0008584 male gonad development GO:0045944 positive regulation of transcription from RNA polymerase II promoter