Human Gene TSPAN4 (ENST00000397397.7) from GENCODE V44
Description: Homo sapiens tetraspanin 4 (TSPAN4), transcript variant 5, mRNA. (from RefSeq NM_003271) RefSeq Summary (NM_003271): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000397397.7 Gencode Gene: ENSG00000214063.12 Transcript (Including UTRs) Position: hg38 chr11:842,852-867,111 Size: 24,260 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr11:850,305-866,630 Size: 16,326 Coding Exon Count: 7
ID:TSN4_HUMAN DESCRIPTION: RecName: Full=Tetraspanin-4; Short=Tspan-4; AltName: Full=Novel antigen 2; Short=NAG-2; AltName: Full=Transmembrane 4 superfamily member 7; SUBUNIT: Forms a complex with integrins. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets. SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14817
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
