Human Gene NLRP10 (ENST00000328600.3) from GENCODE V44
Description: Homo sapiens NLR family pyrin domain containing 10 (NLRP10), mRNA. (from RefSeq NM_176821) RefSeq Summary (NM_176821): Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000328600.3 Gencode Gene: ENSG00000182261.5 Transcript (Including UTRs) Position: hg38 chr11:7,957,537-7,963,657 Size: 6,121 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr11:7,959,644-7,963,495 Size: 3,852 Coding Exon Count: 2
ID:NAL10_HUMAN DESCRIPTION: RecName: Full=NACHT, LRR and PYD domains-containing protein 10; AltName: Full=Nucleotide-binding oligomerization domain protein 8; FUNCTION: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. SUBUNIT: Oligomerizes. Interacts with PYCARD, CASP1 and IL1B. TISSUE SPECIFICITY: Widely expressed with highest levels in heart, brain and skeletal muscle. SIMILARITY: Belongs to the NLRP family. SIMILARITY: Contains 1 DAPIN domain. SIMILARITY: Contains 1 NACHT domain. CAUTION: In contradiction with its official name, it does not contains LRR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86W26
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
