Human Gene ARHGAP1 (ENST00000311956.9) from GENCODE V44
Description: Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA. (from RefSeq NM_004308) RefSeq Summary (NM_004308): This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000311956.9 Gencode Gene: ENSG00000175220.12 Transcript (Including UTRs) Position: hg38 chr11:46,677,080-46,700,619 Size: 23,540 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr11:46,679,037-46,696,107 Size: 17,071 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q07960
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction GO:0007266 Rho protein signal transduction GO:0009967 positive regulation of signal transduction GO:0016197 endosomal transport GO:0033572 transferrin transport GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0098706 ferric iron import across plasma membrane GO:2001136 negative regulation of endocytic recycling
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